Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma.
J Ethnopharmacol
; 282: 114574, 2022 Jan 10.
Article
in English
| MEDLINE | ID: covidwho-1373117
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Gekko gecko is used as a traditional medicine for various diseases including respiratory disorders in northeast Asian countries, mainly Korea, Japan, and China. AIM OF THE STUDY Allergic asthma is a chronic respiratory disease caused by an inappropriate immune response. Due to the recent spread of coronavirus disease 2019, interest in the treatment of pulmonary disorders has rapidly increased. In this study, we investigated the anti-asthmatic effects of G. gecko extract (GGE) using an established mouse model of ovalbumin-induced asthma. MATERIALS AND METHODS:
To evaluate the anti-asthmatic effects of GGE, we evaluated histological changes and the responses of inflammatory mediators related to allergic airway inflammation. Furthermore, we investigated the regulatory effects of GGE on type 2 helper T (Th2) cell activation.RESULTS:
Administration of GGE attenuated asthmatic phenotypes, including inflammatory cell infiltration, mucus production, and expression of Th2 cytokines. Furthermore, GGE treatment reduced Th2 cell activation and differentiation.CONCLUSIONS:
These results indicate that GGE alleviates allergic airway inflammation by regulating Th2 cell activation and differentiation.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
Plant Extracts
/
Ovalbumin
/
Anti-Asthmatic Agents
/
Medicine, East Asian Traditional
/
Mucus
Type of study:
Experimental Studies
Topics:
Traditional medicine
Limits:
Animals
Language:
English
Journal:
J Ethnopharmacol
Year:
2022
Document Type:
Article
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