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Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma.
Nam, Hyeon Hwa; Lee, Ji Hye; Ryu, Seung Mok; Lee, Sueun; Yang, Sungyu; Noh, Pureum; Moon, Byung Cheol; Kim, Joong Sun; Seo, Yun-Soo.
  • Nam HH; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea. Electronic address: namhh@kiom.re.kr.
  • Lee JH; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea; College of Korean Medicine, Semyung University, 65 Semyung-ro, Jecheon, Chungbuk, 27126, South Korea. Electronic address: leejh@semyung.ac.kr.
  • Ryu SM; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea. Electronic address: smryu@kiom.re.kr.
  • Lee S; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea. Electronic address: leese@kiom.re.kr.
  • Yang S; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea. Electronic address: sgyang81@kiom.re.kr.
  • Noh P; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea. Electronic address: pureum322@kiom.re.kr.
  • Moon BC; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea. Electronic address: bcmoon@kiom.re.kr.
  • Kim JS; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea; College of Veterinary Medicine, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea. Electronic address: centraline@jnu.ac.kr.
  • Seo YS; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, 58245, South Korea. Electronic address: sys0109@kiom.re.kr.
J Ethnopharmacol ; 282: 114574, 2022 Jan 10.
Article in English | MEDLINE | ID: covidwho-1373117
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Gekko gecko is used as a traditional medicine for various diseases including respiratory disorders in northeast Asian countries, mainly Korea, Japan, and China. AIM OF THE STUDY Allergic asthma is a chronic respiratory disease caused by an inappropriate immune response. Due to the recent spread of coronavirus disease 2019, interest in the treatment of pulmonary disorders has rapidly increased. In this study, we investigated the anti-asthmatic effects of G. gecko extract (GGE) using an established mouse model of ovalbumin-induced asthma. MATERIALS AND

METHODS:

To evaluate the anti-asthmatic effects of GGE, we evaluated histological changes and the responses of inflammatory mediators related to allergic airway inflammation. Furthermore, we investigated the regulatory effects of GGE on type 2 helper T (Th2) cell activation.

RESULTS:

Administration of GGE attenuated asthmatic phenotypes, including inflammatory cell infiltration, mucus production, and expression of Th2 cytokines. Furthermore, GGE treatment reduced Th2 cell activation and differentiation.

CONCLUSIONS:

These results indicate that GGE alleviates allergic airway inflammation by regulating Th2 cell activation and differentiation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Plant Extracts / Ovalbumin / Anti-Asthmatic Agents / Medicine, East Asian Traditional / Mucus Type of study: Experimental Studies Topics: Traditional medicine Limits: Animals Language: English Journal: J Ethnopharmacol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Plant Extracts / Ovalbumin / Anti-Asthmatic Agents / Medicine, East Asian Traditional / Mucus Type of study: Experimental Studies Topics: Traditional medicine Limits: Animals Language: English Journal: J Ethnopharmacol Year: 2022 Document Type: Article