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Type I Interferons in COVID-19 Pathogenesis.
Palermo, Enrico; Di Carlo, Daniele; Sgarbanti, Marco; Hiscott, John.
  • Palermo E; Istituto Pasteur Italia-Cenci Bolognetti Foundation, Viale Regina Elena 291, 00161 Rome, Italy.
  • Di Carlo D; Istituto Pasteur Italia-Cenci Bolognetti Foundation, Viale Regina Elena 291, 00161 Rome, Italy.
  • Sgarbanti M; Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
  • Hiscott J; Istituto Pasteur Italia-Cenci Bolognetti Foundation, Viale Regina Elena 291, 00161 Rome, Italy.
Biology (Basel) ; 10(9)2021 Aug 26.
Article in English | MEDLINE | ID: covidwho-1374289
ABSTRACT
Among the many activities attributed to the type I interferon (IFN) multigene family, their roles as mediators of the antiviral immune response have emerged as important components of the host response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Viruses likewise have evolved multiple immune evasion strategies to circumvent the host immune response and promote virus propagation and dissemination. Therefore, a thorough characterization of host-virus interactions is essential to understand SARS-CoV-2 pathogenesis. Here, we summarize the virus-mediated evasion of the IFN responses and the viral functions involved, the genetic basis of IFN production in SARS-CoV-2 infection and the progress of clinical trials designed to utilize type I IFN as a potential therapeutic tool.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Biology10090829

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Biology10090829