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The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host's Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19.
Nezametdinova, Venera Z; Yunes, Roman A; Dukhinova, Marina S; Alekseeva, Maria G; Danilenko, Valery N.
  • Nezametdinova VZ; Laboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.
  • Yunes RA; Laboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.
  • Dukhinova MS; International Institute 'Solution Chemistry of Advanced Materials and Technologies', ITMO University, 197101 Saint-Petersburg, Russia.
  • Alekseeva MG; Laboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.
  • Danilenko VN; Laboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.
Int J Mol Sci ; 22(17)2021 Aug 26.
Article in English | MEDLINE | ID: covidwho-1374425
ABSTRACT
Bifidobacteria are some of the major agents that shaped the immune system of many members of the animal kingdom during their evolution. Over recent years, the question of concrete mechanisms underlying the immunomodulatory properties of bifidobacteria has been addressed in both animal and human studies. A possible candidate for this role has been discovered recently. The PFNA cluster, consisting of five core genes, pkb2, fn3, aaa-atp, duf58, tgm, has been found in all gut-dwelling autochthonous bifidobacterial species of humans. The sensory region of the species-specific serine-threonine protein kinase (PKB2), the transmembrane region of the microbial transglutaminase (TGM), and the type-III fibronectin domain-containing protein (FN3) encoded by the I gene imply that the PFNA cluster might be implicated in the interaction between bacteria and the host immune system. Moreover, the FN3 protein encoded by one of the genes making up the PFNA cluster, contains domains and motifs of cytokine receptors capable of selectively binding TNF-α. The PFNA cluster could play an important role for sensing signals of the immune system. Among the practical implications of this finding is the creation of anti-inflammatory drugs aimed at alleviating cytokine storms, one of the dire consequences resulting from SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Proteins / Bifidobacterium / Protein Serine-Threonine Kinases / COVID-19 Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22179219

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Proteins / Bifidobacterium / Protein Serine-Threonine Kinases / COVID-19 Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22179219