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Specific Risk Factors for Fatal Outcome in Critically Ill COVID-19 Patients: Results from a European Multicenter Study.
Meintrup, David; Borgmann, Stefan; Seidl, Karlheinz; Stecher, Melanie; Jakob, Carolin E M; Pilgram, Lisa; Spinner, Christoph D; Rieg, Siegbert; Isberner, Nora; Hower, Martin; Vehreschild, Maria; Göpel, Siri; Hanses, Frank; Nowak-Machen, Martina.
  • Meintrup D; Faculty of Engineering and Management, University of Applied Sciences Ingolstadt, 85049 Ingolstadt, Germany.
  • Borgmann S; Department of Infectious Diseases and Infection Control, Ingolstadt Hospital, 85049 Ingolstadt, Germany.
  • Seidl K; Department of Cardiology, Ingolstadt Hospital, 85049 Ingolstadt, Germany.
  • Stecher M; Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
  • Jakob CEM; German Center for Infection Research (DZIF), Partner-Site Bonn-Cologne, 50937 Cologne, Germany.
  • Pilgram L; Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
  • Spinner CD; German Center for Infection Research (DZIF), Partner-Site Bonn-Cologne, 50937 Cologne, Germany.
  • Rieg S; Department of Internal Medicine, Hematology and Oncology, Goethe University Frankfurt, 60323 Frankfurt, Germany.
  • Isberner N; Department of Internal Medicine II, University Hospital Rechts Der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
  • Hower M; German Center for Infection Research (DZIF), 38106 Brunswick, Germany.
  • Vehreschild M; Department of Medicine II, University of Freiburg, 79106 Freiburg, Germany.
  • Göpel S; Division of Infectious Diseases, Department of Internal Medicine II, University Hospital Würzburg, 97080 Würzburg, Germany.
  • Hanses F; Department of Pneumology, Infectious Diseases, Internal Medicine and Intensive Care, Klinikum Dortmund gGmbH, 44137 Dortmund, Germany.
  • Nowak-Machen M; Department of Infectious Diseases, University Hospital Frankfurt, 60590 Frankfurt, Germany.
J Clin Med ; 10(17)2021 Aug 27.
Article in English | MEDLINE | ID: covidwho-1374437
ABSTRACT
(1)

Background:

The aim of our study was to identify specific risk factors for fatal outcome in critically ill COVID-19 patients. (2)

Methods:

Our data set consisted of 840 patients enclosed in the LEOSS registry. Using lasso regression for variable selection, a multifactorial logistic regression model was fitted to the response variable survival. Specific risk factors and their odds ratios were derived. A nomogram was developed as a graphical representation of the model. (3)

Results:

14 variables were identified as independent factors contributing to the risk of death for critically ill COVID-19 patients age (OR 1.08, CI 1.06-1.10), cardiovascular disease (OR 1.64, CI 1.06-2.55), pulmonary disease (OR 1.87, CI 1.16-3.03), baseline Statin treatment (0.54, CI 0.33-0.87), oxygen saturation (unit = 1%, OR 0.94, CI 0.92-0.96), leukocytes (unit 1000/µL, OR 1.04, CI 1.01-1.07), lymphocytes (unit 100/µL, OR 0.96, CI 0.94-0.99), platelets (unit 100,000/µL, OR 0.70, CI 0.62-0.80), procalcitonin (unit ng/mL, OR 1.11, CI 1.05-1.18), kidney failure (OR 1.68, CI 1.05-2.70), congestive heart failure (OR 2.62, CI 1.11-6.21), severe liver failure (OR 4.93, CI 1.94-12.52), and a quick SOFA score of 3 (OR 1.78, CI 1.14-2.78). The nomogram graphically displays the importance of these 14 factors for mortality. (4)

Conclusions:

There are risk factors that are specific to the subpopulation of critically ill COVID-19 patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10173855

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10173855