Your browser doesn't support javascript.
Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition.
Arrieta, Francisco; Martinez-Vaello, Victoria; Bengoa, Nuria; Rosillo, Marta; de Pablo, Angélica; Voguel, Cristina; Pintor, Rosario; Belanger-Quintana, Amaya; Mateo-Lobo, Raquel; Candela, Angel; Botella-Carretero, José I.
  • Arrieta F; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Martinez-Vaello V; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn) & Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain.
  • Bengoa N; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Rosillo M; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • de Pablo A; Department of Biochemistry, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Voguel C; Department of Anesthesiology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Pintor R; Department of Anesthesiology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Belanger-Quintana A; Department of Pharmacy, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Mateo-Lobo R; Department of Pediatrics, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Candela A; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
  • Botella-Carretero JI; Department of Anesthesiology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Nutrients ; 13(9)2021 Aug 28.
Article in English | MEDLINE | ID: covidwho-1374478
ABSTRACT
We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care unit (ICU), 26 with COVID-19 and 26 non-COVID-19, were included. Glycemic control, delivery of artificial nutrition, serum osteocalcin, total and ICU stays, and mortality were recorded. Patients with COVID-19 had higher ICU stays, were on artificial nutrition for longer (p = 0.004), and needed more frequently insulin infusion therapy (p = 0.022) to control stress hyperglycemia. The need for insulin infusion therapy was associated with higher energy (p = 0.001) and glucose delivered through artificial nutrition (p = 0.040). Those patients with stress hyperglycemia showed higher ICU stays (23 ± 17 vs. 11 ± 13 days, p = 0.007). Serum osteocalcin was a good marker for hyperglycemia, as it inversely correlated with glycemia at admission in the ICU (r = -0.476, p = 0.001) and at days 2 (r = -0.409, p = 0.007) and 3 (r = -0.351, p = 0.049). In conclusion, hyperglycemia in critically ill COVID-19 patients was associated with longer ICU stays. Low circulating osteocalcin was a good marker for stress hyperglycemia.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Osteocalcin / Parenteral Nutrition / SARS-CoV-2 / COVID-19 / Hyperglycemia Type of study: Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Nu13093010

Full text: Available Collection: International databases Database: MEDLINE Main subject: Osteocalcin / Parenteral Nutrition / SARS-CoV-2 / COVID-19 / Hyperglycemia Type of study: Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Nu13093010