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The Anti-SARS-CoV-2 Antibody Response in a Centenarian Woman: A Case of Long-Term Memory?
Toppi, Elisa; De Molfetta, Veronica; Zarletti, Gianpaolo; Tiberi, Massimo; Bossù, Paola; Scapigliati, Giuseppe.
  • Toppi E; IRCCS Fondazione Santa Lucia, Experimental Neuropsychobiology Lab, via del Fosso di Fiorano 64, 00143 Roma, Italy.
  • De Molfetta V; Dipartimento Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01100 Viterbo, Italy.
  • Zarletti G; Dipartimento Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01100 Viterbo, Italy.
  • Tiberi M; Dipartimento Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01100 Viterbo, Italy.
  • Bossù P; IRCCS Fondazione Santa Lucia, Experimental Neuropsychobiology Lab, via del Fosso di Fiorano 64, 00143 Roma, Italy.
  • Scapigliati G; Dipartimento Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01100 Viterbo, Italy.
Viruses ; 13(9)2021 08 27.
Article in English | MEDLINE | ID: covidwho-1374536
ABSTRACT
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic, causing respiratory syndrome and other manifestations. The clinical consequences of the SARS-CoV-2 infection are highly heterogeneous, ranging from asymptomatic and mild to severe and fatal conditions, with the highest mortality rate reached among elderly people. Such heterogeneity appears strongly influenced by the host immune response, which in turn is profoundly affected by aging. In fact, the occurrence of a low-grade inflammation and a decline in specific immune defense is generally reported in older people. Although the low ability of B cells to provide primary and secondary specific responses with a consequent increase in susceptibility to and severity of virus infections is generally described in elderly people, we would like to present here the particular case of a 100-year-old woman, who recovered well from COVID-19 and developed a long-term memory against SARS-CoV-2. Following the infection, the patient's blood was tested with both a classical ELISA and a specific Cell-ELISA addressed to measure the anti-spike S1 specific IgG released in plasma or produced in vitro by memory B cells, respectively. While showing negative on classical serological testing, the patient's blood was positive in Cell-ELISA up to 1 year after the infection. Our observation highlights a potential mechanism of B cell-dependent, long-term protection in response to SARS-CoV-2 infection, suggesting that in a case of successful aging, the absence of specific antibodies in serum does not necessarily mean the absence of immune memory.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Immunologic Memory / Antibodies, Viral Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13091704

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Immunologic Memory / Antibodies, Viral Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13091704