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Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin.
Soria-Castro, Rodolfo; Meneses-Preza, Yatsiri G; Rodríguez-López, Gloria M; Romero-Ramírez, Sandra; Sosa-Hernández, Víctor A; Cervantes-Díaz, Rodrigo; Pérez-Fragoso, Alfredo; Torres-Ruíz, José J; Gómez-Martín, Diana; Campillo-Navarro, Marcia; Álvarez-Jiménez, Violeta D; Pérez-Tapia, Sonia M; Chávez-Blanco, Alma D; Estrada-Parra, Sergio; Maravillas-Montero, José L; Chacón-Salinas, Rommel.
  • Soria-Castro R; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico City, Mexico.
  • Meneses-Preza YG; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico City, Mexico.
  • Rodríguez-López GM; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico City, Mexico.
  • Romero-Ramírez S; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Sosa-Hernández VA; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Cervantes-Díaz R; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Pérez-Fragoso A; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
  • Torres-Ruíz JJ; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Gómez-Martín D; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Campillo-Navarro M; Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Álvarez-Jiménez VD; Departamento de Atención Institucional Continua y Urgencias, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Pérez-Tapia SM; Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Chávez-Blanco AD; Research Coordination, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico.
  • Estrada-Parra S; Lab. de Biología Molecular y Bioseguridad Nivel 3. Centro Médico Naval-SEMAR, Mexico City, Mexico.
  • Maravillas-Montero JL; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico City, Mexico.
  • Chacón-Salinas R; Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico City, Mexico.
J Leukoc Biol ; 110(3): 425-431, 2021 09.
Article in English | MEDLINE | ID: covidwho-1375609
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection ranging from protection to tissue damage and all occur in the development of acute respiratory distress syndrome (ARDS). ARDS patients display elevated levels of inflammatory cytokines and innate immune cells, and T and B cell lymphocytes have been implicated in this dysregulated immune response. Mast cells are abundant resident cells of the respiratory tract and are able to release different inflammatory mediators rapidly following stimulation. Recently, mast cells have been associated with tissue damage during viral infections, but their role in SARS-CoV-2 infection remains unclear. In this study, we examined the profile of mast cell activation markers in the serum of COVID-19 patients. We noticed that SARS-CoV-2-infected patients showed increased carboxypeptidase A3 (CPA3) and decreased serotonin levels in their serum when compared with symptomatic SARS-CoV-2-negative patients. CPA3 levels correlated with C-reactive protein, the number of circulating neutrophils, and quick SOFA. CPA3 in serum was a good biomarker for identifying severe COVID-19 patients, whereas serotonin was a good predictor of SARS-CoV-2 infection. In summary, our results show that serum CPA3 and serotonin levels are relevant biomarkers during SARS-CoV-2 infection. This suggests that mast cells and basophils are relevant players in the inflammatory response in COVID-19 and may represent targets for therapeutic intervention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serotonin / Inflammation Mediators / Carboxypeptidases A / SARS-CoV-2 / COVID-19 / Inflammation / Mast Cells Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Leukoc Biol Year: 2021 Document Type: Article Affiliation country: JLB.4HI0221-087R

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serotonin / Inflammation Mediators / Carboxypeptidases A / SARS-CoV-2 / COVID-19 / Inflammation / Mast Cells Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Leukoc Biol Year: 2021 Document Type: Article Affiliation country: JLB.4HI0221-087R