Your browser doesn't support javascript.
Interfering with SARS-CoV-2: are interferons friends or foes in COVID-19?
Zanoni, Ivan.
  • Zanoni I; Harvard Medical School, and Division of Immunology, Division of Gastroenterology, Boston Children's Hospital, United States. Electronic address: ivan.zanoni@childrens.harvard.edu.
Curr Opin Virol ; 50: 119-127, 2021 10.
Article in English | MEDLINE | ID: covidwho-1375918
ABSTRACT
Type I and type III interferons are among the most potent anti-viral cytokines produced by the immune system. The recent outbreak of SARS-CoV-2, which causes COVID-19, underscores the vital role of these cytokines in controlling the virus and dictating disease severity. Here we delineate the pathways that lead to interferon production in response to SARS-CoV-2 encounter, and elucidate how this virus hinders the production and action of these cytokines; we also highlight that these interferon families serve protective as well as detrimental roles in patients with COVID-19, and conclude that a better understanding of the time, dose, localization, and activity of specific members of the interferon families is imperative for designing more efficient therapeutic interventions against this disease.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferons / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferons / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article