Covid-19 interface with drug misuse and substance use disorders.
Neuropharmacology
; 198: 108766, 2021 10 15.
Article
in English
| MEDLINE | ID: covidwho-1376075
ABSTRACT
The coronavirus disease 2019 (Covid-19) pandemic intensified the already catastrophic drug overdose and substance use disorder (SUD) epidemic, signaling a syndemic as social isolation, economic and mental health distress, and disrupted treatment services disproportionally impacted this vulnerable population. Along with these social and societal factors, biological factors triggered by intense stress intertwined with incumbent overactivity of the immune system and the resulting inflammatory outcomes may impact the functional status of the central nervous system (CNS). We review the literature concerning SARS-CoV2 infiltration and infection in the CNS and the prospects of synergy between stress, inflammation, and kynurenine pathway function during illness and recovery from Covid-19. Taken together, inflammation and neuroimmune signaling, a consequence of Covid-19 infection, may dysregulate critical pathways and underlie maladaptive changes in the CNS, to exacerbate the development of neuropsychiatric symptoms and in the vulnerability to develop SUD. This article is part of the special Issue on 'Vulnerabilities to Substance Abuse'.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Substance-Related Disorders
/
Drug Misuse
/
SARS-CoV-2
/
COVID-19
Type of study:
Observational study
/
Qualitative research
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuropharmacology
Year:
2021
Document Type:
Article
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