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Sensitivity and specificity of the antigen-based anterior nasal self-testing programme for detecting SARS-CoV-2 infection in schools, Austria, March 2021.
Willeit, Peter; Bernar, Benoît; Zurl, Christoph; Al-Rawi, Mariam; Berghold, Andrea; Bernhard, David; Borena, Wegene; Doppler, Christian; Kerbl, Reinhold; Köhler, Alwin; Krause, Robert; Lamprecht, Bernd; Pröll, Johannes; Schmidt, Hannes; Steinmetz, Ivo; Stelzl, Evelyn; Stoiber, Heribert; von Laer, Dorothee; Zuber, Johannes; Müller, Thomas; Strenger, Volker; Wagner, Michael.
  • Willeit P; Clinical Epidemiology Team, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Bernar B; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Zurl C; Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.
  • Al-Rawi M; Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  • Berghold A; BioTechMed-Graz, Graz, Austria.
  • Bernhard D; Department of Paediatrics and Adolescent Medicine, Division of General Paediatrics, Medical University of Graz, Graz, Austria.
  • Borena W; Vienna Covid-19 Detection Initiative, Vienna, Austria.
  • Doppler C; Max Perutz Labs, University of Vienna, Vienna, Austria.
  • Kerbl R; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
  • Köhler A; Center for Medical Research, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
  • Krause R; Division of Pathophysiology, Institute of Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria.
  • Lamprecht B; Institute of Virology, Medical University Innsbruck, Innsbruck, Austria.
  • Pröll J; Center for Medical Research, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
  • Schmidt H; Division of Pathophysiology, Institute of Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria.
  • Steinmetz I; Department of Paediatrics and Adolescent Medicine, LKH Hochsteiermark, Leoben, Austria.
  • Stelzl E; Vienna Covid-19 Detection Initiative, Vienna, Austria.
  • Stoiber H; Max Perutz Labs, University of Vienna, Vienna, Austria.
  • von Laer D; Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  • Zuber J; BioTechMed-Graz, Graz, Austria.
  • Müller T; Department of Pulmonology, Kepler-University-Hospital, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
  • Strenger V; Center for Medical Research, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria.
  • Wagner M; Centre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.
Euro Surveill ; 26(34)2021 08.
Article in English | MEDLINE | ID: covidwho-1376683
ABSTRACT
This study evaluates the performance of the antigen-based anterior nasal screening programme implemented in all Austrian schools to detect SARS-CoV-2 infections. We combined nationwide antigen-based screening data obtained in March 2021 from 5,370 schools (Grade 1-8) with an RT-qPCR-based prospective cohort study comprising a representative sample of 244 schools. Considering a range of assumptions, only a subset of infected individuals are detected with the programme (low to moderate sensitivity) and non-infected individuals mainly tested negative (very high specificity).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.34.2100797

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.34.2100797