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COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial.
Agrati, Chiara; Di Cosimo, Serena; Fenoglio, Daniela; Apolone, Giovanni; Ciceri, Fabio; Ciliberto, Gennaro; Baldanti, Fausto; Costantini, Massimo; Giannarelli, Diana; Ippolito, Giuseppe; Locatelli, Franco; Mantovani, Alberto; Morrone, Aldo; Tagliavini, Fabrizio; Uccelli, Antonio; Zinzani, Pier Luigi; Silvestris, Nicola; Rescigno, Maria.
  • Agrati C; Cellular Immunology Laboratory, Department of Epidemiology, Preclinical Research and Advanced Diagnostic, National Institute for Infectious Diseases (INMI) Lazzaro Spallanzani - IRCCS, Roma, Italy.
  • Di Cosimo S; Biomarkers Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
  • Fenoglio D; Department of Internal Medicine and Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
  • Apolone G; Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Ciceri F; Scientific Directorate, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
  • Ciliberto G; Scientific Directorate, IRCSS San Raffaele Scientific Institute, Milano, Italy.
  • Baldanti F; IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy.
  • Costantini M; Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo; Dpt. of Clinical, Surgical, Diagnostics and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Giannarelli D; Scientific Directorate, Azienda Unita Sanitaria Locale (USL)-IRCCS Reggio Emilia, Reggio Emilia, Italy.
  • Ippolito G; Biostatistical Unit, Istituto Nazionale Tumori Regina Elena IRCCS - IFO, Rome, Italy.
  • Locatelli F; Scientific Directorate, INMI Lazzaro Spallanzani - IRCCS, Roma, Italy.
  • Mantovani A; Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Department of Gynecology-Obstetrics and Pediatrics, University "La Sapienza", Roma, Italy.
  • Morrone A; Scientific Directorate, IRCCS Humanitas Clinical and Research Center, Rozzano, Italy.
  • Tagliavini F; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Uccelli A; William Harvey Research Institute, Queen Mary University, London, United Kingdom.
  • Zinzani PL; Scientific Directorate, San Gallicano Dermatological Institute IRCCS, Rome, Italy.
  • Silvestris N; Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  • Rescigno M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.
Front Immunol ; 12: 704110, 2021.
Article in English | MEDLINE | ID: covidwho-1376699
ABSTRACT
Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.704110

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.704110