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SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage.
Karami Fath, Mohsen; Jahangiri, Abolfazl; Ganji, Mahmoud; Sefid, Fatemeh; Payandeh, Zahra; Hashemi, Zahra Sadat; Pourzardosht, Navid; Hessami, Anahita; Mard-Soltani, Maysam; Zakeri, Alireza; Rahbar, Mohammad Reza; Khalili, Saeed.
  • Karami Fath M; Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
  • Jahangiri A; Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Ganji M; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Sefid F; Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Payandeh Z; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hashemi ZS; Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
  • Pourzardosht N; Biochemistry Department, Guilan University of Medical Sciences, Rasht, Iran.
  • Hessami A; School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mard-Soltani M; Department of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical Sciences, Dezful, Iran.
  • Zakeri A; Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.
  • Rahbar MR; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Khalili S; Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.
Front Immunol ; 12: 705772, 2021.
Article in English | MEDLINE | ID: covidwho-1376700
ABSTRACT
Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for its ability to trigger ADs. In this regard, the entire proteome of the SARS-CoV-2 was chopped into more than 48000 peptides. The produced peptides were searched against the entire human proteome to find shared peptides with similar experimentally confirmed T-cell and B-cell epitopes. The obtained peptides were checked for their ability to bind to HLA molecules. The possible population coverage was calculated for the most potent peptides. The obtained results indicated that the SARS-CoV-2 and human proteomes share 23 peptides originated from ORF1ab polyprotein, nonstructural protein NS7a, Surface glycoprotein, and Envelope protein of SARS-CoV-2. Among these peptides, 21 peptides had experimentally confirmed equivalent epitopes. Amongst, only nine peptides were predicted to bind to HLAs with known global allele frequency data, and three peptides were able to bind to experimentally confirmed HLAs of equivalent epitopes. Given the HLAs which have already been reported to be associated with ADs, the ESGLKTIL, RYPANSIV, NVAITRAK, and RRARSVAS were determined to be the most harmful peptides of the SARS-CoV-2 proteome. It would be expected that the COVID-19 pandemic and the vaccination against this pathogen could significantly increase the ADs incidences, especially in populations harboring HLA-B*0801, HLA-A*02402, HLA-A*1101 and HLA-B*2705. The Southeast Asia, East Asia, and Oceania are at higher risk of AD development.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Autoimmunity / Proteome / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.705772

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Autoimmunity / Proteome / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.705772