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Common Themes in Zoonotic Spillover and Disease Emergence: Lessons Learned from Bat- and Rodent-Borne RNA Viruses.
Williams, Evan P; Spruill-Harrell, Briana M; Taylor, Mariah K; Lee, Jasper; Nywening, Ashley V; Yang, Zemin; Nichols, Jacob H; Camp, Jeremy V; Owen, Robert D; Jonsson, Colleen B.
  • Williams EP; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Spruill-Harrell BM; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Taylor MK; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Lee J; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Nywening AV; Department of Clinical Pharmacy and Translational Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Yang Z; Department of Cell and Molecular Biology, St. Jude's Children's Hospital, Memphis, TN 38105, USA.
  • Nichols JH; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Camp JV; Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
  • Owen RD; Centro para el Desarrollo de Investigaciones Científicas, Asunción C.P. 1371, Paraguay.
  • Jonsson CB; Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Viruses ; 13(8)2021 07 31.
Article in English | MEDLINE | ID: covidwho-1376989
ABSTRACT
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest percentage of living mammals on earth. Thus, it is not surprising that these two orders account for many of the reservoirs of the zoonotic RNA viruses discovered to date. The spillover of these viruses from wildlife to human do not typically result in pandemics but rather geographically confined outbreaks of human infection and disease. While limited geographically, these viruses cause thousands of cases of human disease each year. In this review, we focus on three questions regarding zoonotic viruses that originate in bats and rodents. First, what biological strategies have evolved that allow RNA viruses to reside in bats and rodents? Second, what are the environmental and ecological causes that drive viral spillover? Third, how does virus spillover occur from bats and rodents to humans?
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rodentia / Virus Diseases / Disease Reservoirs / Zoonoses / Chiroptera Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13081509

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rodentia / Virus Diseases / Disease Reservoirs / Zoonoses / Chiroptera Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13081509