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The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response.
Botti-Lodovico, Yolanda; Nair, Parvathy; Nosamiefan, Dolo; Stremlau, Matthew; Schaffner, Stephen; Agignoae, Sebastian V; Aiyepada, John Oke; Ajogbasile, Fehintola V; Akpede, George O; Alhasan, Foday; Andersen, Kristian G; Asogun, Danny A; Ayodeji, Oladele Oluwafemi; Badiane, Aida S; Barnes, Kayla; Bauer, Matthew R; Bell-Kareem, Antoinette; Benard, Muoebonam Ekene; Benevolence, Ebo Ohomoime; Blessing, Osiemi; Boehm, Chloe K; Boisen, Matthew L; Bond, Nell G; Branco, Luis M; Butts, Michael J; Carter, Amber; Colubri, Andres; Deme, Awa B; DeRuff, Katherine C; Diédhiou, Younousse; Edamhande, Akhilomen Patience; Elhamoumi, Siham; Engel, Emily J; Eromon, Philomena; Fallah, Mosoka; Folarin, Onikepe A; Fry, Ben; Garry, Robert; Gaye, Amy; Gbakie, Michael; Gevao, Sahr M; Gionet, Gabrielle; Gladden-Young, Adrianne; Goba, Augustine; Gomis, Jules Francois; Happi, Anise N; Houghton, Mary; Ihekwuazu, Chikwe; Iruolagbe, Christopher Ojemiega; Jackson, Jonathan.
  • Botti-Lodovico Y; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Nair P; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  • Nosamiefan D; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
  • Stremlau M; Equator Labs Incorporated, Washington, DC 20011, USA.
  • Schaffner S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Agignoae SV; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Aiyepada JO; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
  • Ajogbasile FV; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Akpede GO; Harvard Kennedy School, Cambridge, MA 02138, USA.
  • Alhasan F; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Andersen KG; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
  • Asogun DA; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.
  • Ayodeji OO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Badiane AS; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.
  • Barnes K; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.
  • Bauer MR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Bell-Kareem A; Scripps Research Translational Institute, La Jolla, CA 92037, USA.
  • Benard ME; Ambrose Alli University, Ekpoma, Edo State, Nigeria.
  • Benevolence EO; Federal Medical Centre, Owo, Ondo State, Nigeria.
  • Blessing O; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal.
  • Boehm CK; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Boisen ML; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
  • Bond NG; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  • Branco LM; Tulane University Medical Center, New Orleans, LA 70112, USA.
  • Butts MJ; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Carter A; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Colubri A; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Deme AB; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • DeRuff KC; Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
  • Diédhiou Y; Zalgen Labs, Germantown, MD 20876, USA.
  • Edamhande AP; Tulane University Medical Center, New Orleans, LA 70112, USA.
  • Elhamoumi S; Zalgen Labs, Germantown, MD 20876, USA.
  • Engel EJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Eromon P; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Fallah M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Folarin OA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Fry B; University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Garry R; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal.
  • Gaye A; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Gbakie M; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal.
  • Gevao SM; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Gionet G; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Gladden-Young A; Tulane University Medical Center, New Orleans, LA 70112, USA.
  • Goba A; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
  • Gomis JF; Refuge Place International, Bassa Town, Lower Johnsonville, Liberia.
  • Happi AN; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
  • Houghton M; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.
  • Ihekwuazu C; Fathom Information Design, Boston, MA 02114, USA.
  • Iruolagbe CO; Tulane University Medical Center, New Orleans, LA 70112, USA.
  • Jackson J; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Viruses ; 13(8)2021 08 13.
Article in English | MEDLINE | ID: covidwho-1376992
ABSTRACT
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE-detected in the Yoruba population of Nigeria-conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the "emerging" nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz's critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disaster Planning / Lassa Fever / Lassa virus Type of study: Clinical Practice Guide / Prognostic study / Qualitative research Limits: Humans Country/Region as subject: Africa Language: English Year: 2021 Document Type: Article Affiliation country: V13081605

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disaster Planning / Lassa Fever / Lassa virus Type of study: Clinical Practice Guide / Prognostic study / Qualitative research Limits: Humans Country/Region as subject: Africa Language: English Year: 2021 Document Type: Article Affiliation country: V13081605