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Elements of Th1/Th2 response and disease severity in COVID-19 patients: A short report.
Akinosoglou, Karolina; Delastic, Anne-Lise; Dimakopoulou, Vasilina; Marangos, Markos; Gogos, Charalambos.
  • Akinosoglou K; Department of Internal Medicine, University of Patras, Rio, Greece.
  • Delastic AL; Department of Infectious Diseases, University of Patras, Rio, Greece.
  • Dimakopoulou V; Department of Internal Medicine, University of Patras, Rio, Greece.
  • Marangos M; Department of Internal Medicine, University of Patras, Rio, Greece.
  • Gogos C; Department of Internal Medicine, University of Patras, Rio, Greece.
J Med Virol ; 94(1): 404-406, 2022 01.
Article in English | MEDLINE | ID: covidwho-1377591
ABSTRACT
The presence of a complex immune dysregulation syndrome has been established in COVID-19 patients. We aimed to assess Th1/Th2 response in COVID-19 patients and its association with disease severity by performing a prospective cohort study in a tertiary hospital COVID-19 referral center. We report no difference between Th1/Th2 responses between patients with severe and mild disease, except for levels of interleukin-6 (IL-6) and IL-10. Future larger studies should examine lung-specific versus systemic inflammatory responses, as well as, diverse immunotypes driving poor clinical outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-6 / Interleukin-10 / Th2 Cells / Th1 Cells / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27313

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-6 / Interleukin-10 / Th2 Cells / Th1 Cells / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27313