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ANMCO POSITION PAPER: Use of sacubitril/valsartan in hospitalized patients with acute heart failure.
Di Tano, Giuseppe; Di Lenarda, Andrea; Iacoviello, Massimo; Oliva, Fabrizio; Urbinati, Stefano; Aspromonte, Nadia; Cipriani, Manlio; Caldarola, Pasquale; Murrone, Adriano; Gulizia, Michele Massimo; Colivicchi, Furio; Gabrielli, Domenico.
  • Di Tano G; Cardiology Department, Ospedale, ASST di Cremona, Cremona, Italy.
  • Di Lenarda A; Cardiovascolular and Sports Medicine Department, Azienda Sanitaria Universitaria Giuliano Isontina-ASUGI, Trieste, Italy.
  • Iacoviello M; Cardiology Department, AOU Policlinico Riuniti di Foggia, Dipartimento delle Scienze Mediche e Chirurgiche, Università degli Studi, Foggia, Italy.
  • Oliva F; Cardiology 1-Cath Lab, CCU, Dipartimento Cardiotoracovascolare 'A. De Gasperis', ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Urbinati S; Cardiology Department, Ospedale Bellaria, AUSL di Bologna, Bologna, Italy.
  • Aspromonte N; Heart Failure Unit, Department of Cardiovascular ad Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
  • Cipriani M; Cardiology 2-Heart Failure and Transplants, Dipartimento Cardiotoracovascolare 'A. De Gasperis', ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Caldarola P; Cardiology Department, Ospedale San Paolo, Bari, Italy.
  • Murrone A; Cardiology-CCU Department, Ospedali di Città di Castello e di Gubbio-Gualdo Tadino, AUSL Umbria 1, Perugia, Italy.
  • Gulizia MM; Cardiology Department, Ospedale Garibaldi-Nesima, Azienda di Rilievo Nazionale e Alta Specializzazione 'Garibaldi', Catania, Italy.
  • Colivicchi F; Fondazione per il Tuo cuore-Heart Care Foundation, Firenze, Italy.
  • Gabrielli D; Clinical and Rehabilitation Cardiology, Presidio Ospedaliero San Filippo Neri-ASL Roma 1, Roma, Italy.
Eur Heart J Suppl ; 23(Suppl C): C176-C183, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1377967
ABSTRACT
Sacubitril/valsartan (S/V) has been shown to reduce the risk of cardiovascular death or heart failure hospitalization and improve symptoms in chronic heart failure with reduced ejection fraction compared with enalapril. After 7 years since the publication of the results of PARADIGM-HF, further insight has been gained with potential new indications. Two prospective randomized multicentre studies (PIONEER-HF and TRANSITION) in patients hospitalized for acute heart failure (AHF) have shown an improved clinical outcome and biomarker profile as compared with enalapril, and good tolerability, safety, and feasibility of initiating in-hospital administration of S/V. Furthermore, some studies have highlighted the favourable effects of S/V in attenuating adverse myocardial remodelling, supporting an early benefit after treatment. Observational data from non-randomized studies in AHF report that in-hospital and pre-discharge prescription of evidence-based drugs associated with better survival still remain suboptimal. Additionally, the COVID-19 pandemic has also negatively impacted on outpatient activities. Therefore, hospitalization, a real crossroad in the history of heart failure, must become a management and therapeutic opportunity for our patients. The objective of this ANMCO position paper is to encourage and facilitate early S/V administration in stabilized patients during hospitalization after an AHF episode, with the aim of improving care efficiency and clinical outcome.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Eur Heart J Suppl Year: 2021 Document Type: Article Affiliation country: Eurheartj

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Eur Heart J Suppl Year: 2021 Document Type: Article Affiliation country: Eurheartj