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Investigation of the stability and risks of fomite transmission of human coronavirus OC43 on leather.
Shivkumar, Maitreyi; Adkin, Pat; Owen, Lucy; Laird, Katie.
  • Shivkumar M; Infectious Disease Research Group, The Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
  • Adkin P; Infectious Disease Research Group, The Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
  • Owen L; Infectious Disease Research Group, The Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
  • Laird K; Infectious Disease Research Group, The Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
FEMS Microbiol Lett ; 368(16)2021 09 01.
Article in English | MEDLINE | ID: covidwho-1377968
ABSTRACT
Limited research exists on the potential for leather to act as a fomite of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or endemic coronaviruses including human coronavirus (HCoV) OC43; this is important for settings such as the shoe manufacturing industry. Antiviral coating of leather hides could limit such risks. This study aimed to investigate the stability and transfer of HCoVOC43 on different leathers, as a surrogate for SARS-CoV-2, and assess the antiviral efficacy of a silver-based leather coating. The stability of HCoV-OC43 (6.6 log10) on patent, full-grain calf, corrected grain finished and nubuck leathers (silver additive-coated and uncoated) was measured by titration on BHK-21 cells. Transfer from leather to cardboard and stainless steel was determined. HCoV-OC43 was detectable for 6 h on patent, 24 h on finished leather and 48 h on calf leather; no infectious virus was recovered from nubuck. HCoV-OC43 transferred from patent, finished and calf leathers onto cardboard and stainless steel up to 2 h post-inoculation (≤3.1-5.5 log10), suggesting that leathers could act as fomites. Silver additive-coated calf and finished leathers were antiviral against HCoV-OC43, with no infectious virus recovered after 2 h and limited transfer to other surfaces. The silver additive could reduce potential indirect transmission of HCoV-OC43 from leather.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus OC43, Human / Fomites Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Femsle

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus OC43, Human / Fomites Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Femsle