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Drug targets for corona virus: A systematic review.
Prajapat, Manisha; Sarma, Phulen; Shekhar, Nishant; Avti, Pramod; Sinha, Shweta; Kaur, Hardeep; Kumar, Subodh; Bhattacharyya, Anusuya; Kumar, Harish; Bansal, Seema; Medhi, Bikash.
  • Prajapat M; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Sarma P; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Shekhar N; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Avti P; Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Sinha S; Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Kaur H; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Kumar S; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Bhattacharyya A; Departments of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.
  • Kumar H; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Bansal S; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Medhi B; Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Pharmacol ; 52(1): 56-65, 2020.
Article in English | MEDLINE | ID: covidwho-13780
ABSTRACT
The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21th century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Proteins / Drug Design / Coronavirus Infections / Betacoronavirus Type of study: Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Humans Language: English Journal: Indian J Pharmacol Year: 2020 Document Type: Article Affiliation country: Ijp.IJP_115_20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Proteins / Drug Design / Coronavirus Infections / Betacoronavirus Type of study: Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Humans Language: English Journal: Indian J Pharmacol Year: 2020 Document Type: Article Affiliation country: Ijp.IJP_115_20