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Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID-19-Mechanisms and Therapeutic Targets.
Fodor, Adriana; Tiperciuc, Brandusa; Login, Cezar; Orasan, Olga H; Lazar, Andrada L; Buchman, Cristina; Hanghicel, Patricia; Sitar-Taut, Adela; Suharoschi, Ramona; Vulturar, Romana; Cozma, Angela.
  • Fodor A; Clinical Center of Diabetes, Nutrition, and Metabolic Diseases, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, CJ, Romania.
  • Tiperciuc B; Department of Pharmaceutical Chemistry, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Login C; Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, CJ, Romania.
  • Orasan OH; Internal Medicine Department, 4th Medical Clinic "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Lazar AL; Department of Dermatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
  • Buchman C; Department of Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
  • Hanghicel P; Department of Neurology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Sitar-Taut A; Internal Medicine Department, 4th Medical Clinic "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Suharoschi R; Department of Food Science, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
  • Vulturar R; Department of Molecular Sciences, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Cozma A; Internal Medicine Department, 4th Medical Clinic "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Oxid Med Cell Longev ; 2021: 8671713, 2021.
Article in English | MEDLINE | ID: covidwho-1378091
ABSTRACT
The outbreak of the COVID-19 pandemic represents an ongoing healthcare emergency responsible for more than 3.4 million deaths worldwide. COVID-19 is the disease caused by SARS-CoV-2, a virus that targets not only the lungs but also the cardiovascular system. COVID-19 can manifest with a wide range of clinical manifestations, from mild symptoms to severe forms of the disease, characterized by respiratory failure due to severe alveolar damage. Several studies investigated the underlying mechanisms of the severe lung damage associated with SARS-CoV-2 infection and revealed that the respiratory failure associated with COVID-19 is the consequence not only of acute respiratory distress syndrome but also of macro- and microvascular involvement. New observations show that COVID-19 is an endothelial disease, and the consequent endotheliopathy is responsible for inflammation, cytokine storm, oxidative stress, and coagulopathy. In this review, we show the central role of endothelial dysfunction, inflammation, and oxidative stress in the COVID-19 pathogenesis and present the therapeutic targets deriving from this endotheliopathy.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vascular Diseases / Endothelium, Vascular / Oxidative Stress / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Inflammation Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Oxid Med Cell Longev Journal subject: Metabolism Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vascular Diseases / Endothelium, Vascular / Oxidative Stress / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Inflammation Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Oxid Med Cell Longev Journal subject: Metabolism Year: 2021 Document Type: Article Affiliation country: 2021