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iciHHV-6 in a Patient With Multisystem Inflammatory Syndrome in Children.
Biswas, Lisa; Crain, Noreen; Spaeder, Michael C; Gomez, Robert J; Starolis, Meghan; Poulter, Melinda D; Zeichner, Steven L.
  • Biswas L; Department of Pediatrics, University of Virginia, Charlottesville, Virginia.
  • Crain N; Division of Pediatric Critical Care Medicine.
  • Spaeder MC; Division of Pediatric Critical Care Medicine.
  • Gomez RJ; Division of Critical Care Medicine, Children's Hospital of The King's Daughters, Norfolk, Virginia.
  • Starolis M; Quest Diagnostics Nichols Institute Chantilly, Chantilly, Virginia.
  • Poulter MD; Clinical Microbiology Laboratory, Department of Pathology, University of Virginia Health System, Charlottesville, Virginia.
  • Zeichner SL; Department of Microbiology, Immunology, and Cancer Biology, Pendleton Pediatric Infectious Disease Laboratory, and Child Health Research Center zeichner@virginia.edu.
Pediatrics ; 148(3)2021 09.
Article in English | MEDLINE | ID: covidwho-1378143
ABSTRACT
Multisystem inflammatory syndrome in children (MIS-C) is a serious, sometimes life-threatening late complication of coronavirus disease 2019 (COVID-19) with multiorgan involvement and evidence of immune activation. The pathogenesis of MIS-C is not known, nor is the pathogenesis of the severe organ damage that is the hallmark of MIS-C. Human herpesvirus 6 (HHV-6), the virus responsible for roseola, is a ubiquitous herpesvirus that causes close to universal infection by the age of 3 years. HHV-6 remains latent for life and can be activated during inflammatory states, by other viruses, and by host cell apoptosis. HHV-6 has been associated with end-organ diseases, including hepatitis, carditis, and encephalitis. In addition, ∼1% of people have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), which is HHV-6 that has been integrated into chromosomal telomeric regions and is transmitted through the germ line. iciHHV-6 can be reactivated and has been associated with altered immune responses. We report here a case of MIS-C in which an initial high HHV-6 DNA polymerase chain reaction viral load assay prompted testing for iciHHV-6, which yielded a positive result. Additional research may be warranted to determine if iciHHV-6 is commonly observed in patients with MIS-C and, if so, whether it may play a part in MIS-C pathogenesis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Herpesvirus 6, Human / Systemic Inflammatory Response Syndrome / Roseolovirus Infections / COVID-19 Type of study: Case report Limits: Child / Humans / Male Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Herpesvirus 6, Human / Systemic Inflammatory Response Syndrome / Roseolovirus Infections / COVID-19 Type of study: Case report Limits: Child / Humans / Male Language: English Year: 2021 Document Type: Article