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Multisystem inflammatory syndrome with persistent neutropenia in neonate exposed to SARS-CoV-2 virus: A case report and review of literature.
Diwakar, K; Gupta, B K; Uddin, M W; Sharma, A; Jhajra, S.
  • Diwakar K; Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India.
  • Gupta BK; Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India.
  • Uddin MW; Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India.
  • Sharma A; Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Rohtak, Haryana, India.
  • Jhajra S; Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India.
J Neonatal Perinatal Med ; 15(2): 373-377, 2022.
Article in English | MEDLINE | ID: covidwho-1378185
ABSTRACT

BACKGROUND:

Multisystem inflammatory syndrome in Children (MIS-C) is a postinfectious immune mediated hyperinflammatory state seen in children and adolescent below 21 year of age and develop after 4-6 weeks of severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2) infection, however, it is rare in neonates. We report an extremely rare and first of its kind case of MIS-C in a neonate with persistent neutropenia. CASE DESCRIPTION A 19-day old boy presented with complaints of fever and loose stools for 1 day and developed rash after admission. Baby was investigated for sepsis and commenced on IV antibiotics empirically. In view of persistent fever, diarrhoea, rash and absence of obvious microbial etiology of inflammation, with elevated inflammatory marker and an epidemiologic link to SARS-CoV-2 infection, the diagnosis of MIS-C-was made. Intravenous immunoglobulin (IVIg) was administered and defervescence occurred within 24 hours. He also developed neutropenia during course of illness which persisted on follow up.

CONCLUSION:

MIS-C in neonates is uncommon and fever with elevated inflammatory markers during COVID-19 pandemic should alert the pediatrician to the possibility of MIS-C. Neutropenia may be associated with MIS-C in neonates and warrants prolonged follow up.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exanthema / COVID-19 / Neutropenia Type of study: Case report / Cohort study / Etiology study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Humans / Infant / Male / Infant, Newborn Language: English Journal: J Neonatal Perinatal Med Year: 2022 Document Type: Article Affiliation country: NPM-210839

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exanthema / COVID-19 / Neutropenia Type of study: Case report / Cohort study / Etiology study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Humans / Infant / Male / Infant, Newborn Language: English Journal: J Neonatal Perinatal Med Year: 2022 Document Type: Article Affiliation country: NPM-210839