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Impact of social and mobility restrictions in Parkinson's disease during COVID-19 lockdown.
Luis-Martínez, Raquel; Di Marco, Roberto; Weis, Luca; Cianci, Valeria; Pistonesi, Francesca; Baba, Alfonc; Carecchio, Miryam; Biundo, Roberta; Tedesco, Chiara; Masiero, Stefano; Antonini, Angelo.
  • Luis-Martínez R; Department of Neurosciences, University of the Basque Country, (UPV/EHU), Leioa, Spain.
  • Di Marco R; Parkinson and Movement Disorders Unit, Department of Neurosciences, University of Padova, Via Giustiniani 5, 35138, Padua, Italy.
  • Weis L; Parkinson and Movement Disorders Unit, Department of Neurosciences, University of Padova, Via Giustiniani 5, 35138, Padua, Italy.
  • Cianci V; Parkinson and Movement Disorders Unit, Department of Neurosciences, University of Padova, Via Giustiniani 5, 35138, Padua, Italy.
  • Pistonesi F; Parkinson and Movement Disorders Unit, Department of Neurosciences, University of Padova, Via Giustiniani 5, 35138, Padua, Italy.
  • Baba A; Parkinson and Movement Disorders Unit, Department of Neurosciences, University of Padova, Via Giustiniani 5, 35138, Padua, Italy.
  • Carecchio M; Rehabilitation Unit, Azienda Ospedaliera Universitaria di Padova, Padova, Italy.
  • Biundo R; Parkinson and Movement Disorders Unit, Department of Neurosciences, University of Padova, Via Giustiniani 5, 35138, Padua, Italy.
  • Tedesco C; Department of General Psychology, University of Padova, Padova, Italy.
  • Masiero S; Parkinson and Movement Disorders Unit, Department of Neurosciences, University of Padova, Via Giustiniani 5, 35138, Padua, Italy.
  • Antonini A; Physical Medicine and Rehabilitation School, University of Padova, Padova, Italy.
BMC Neurol ; 21(1): 332, 2021 Aug 30.
Article in English | MEDLINE | ID: covidwho-1379784
ABSTRACT

BACKGROUND:

The consequences of strict COVID-19 mobility restrictions on motor/non-motor features in Parkinson's disease (PD) have not been systematically studied but worse mobility and quality of life have been reported. To elucidate this question, 12 mild to moderate PD patients were assessed in March 2020 before and after two months of isolation as part of a clinical study that had to be interrupted due to the pandemic and the implementation of COVID19 mobility restrictions.

METHODS:

Twelve patients were systematically evaluated before and after the lockdown period as part of a larger cohort that previously underwent thermal water rehabilitation. Clinical outcomes were the Body Mass index, the Mini-Balance Evaluation Systems Test, the MDS-Unified Parkinson's Disease Rating Scale part III, the 6 Minute Walking Test and the New Freezing of Gait Questionnaire. Global cognition was evaluated with the Montreal Cognitive Assessment scale. The impact of COVID-19 restrictions on quality of life and functional independence was evaluated with The Parkinson's disease Quality of life (PDQ-39), the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living questionnaires (IADL) and the Parkinson's disease cognitive functional rating scales (PD-CFRS).

RESULTS:

After two months of isolation the Mini-BESTest score worsened (p=0.005), and four patients reported one or more falls during the lockdown. BMI increased (p=0.031) while the remaining clinical variables including quality of life did not change.

CONCLUSION:

We observed moderate worsening at Mini-BESTest, greater risk of falls and increased body weight as consequence of prolonged immobility. We believe negative effects were partially softened since patients were in contact with our multidisciplinary team during the lockdown and had previously received training to respond to the needs of this emergency isolation. These findings highligh the importnace of patient-centered interventions in PD management.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Parkinson Disease / Gait Disorders, Neurologic / Mobility Limitation / COVID-19 Subject: Parkinson Disease / Gait Disorders, Neurologic / Mobility Limitation / COVID-19 Type of study: Etiology study / Patient-preference / Risk factors Language: English Journal: BMC Neurol Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Parkinson Disease / Gait Disorders, Neurologic / Mobility Limitation / COVID-19 Subject: Parkinson Disease / Gait Disorders, Neurologic / Mobility Limitation / COVID-19 Type of study: Etiology study / Patient-preference / Risk factors Language: English Journal: BMC Neurol Clinical aspect: Etiology Year: 2021
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