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Dynamics of humoral response to coronavirus antigens among employees of a designated COVID­19 hospital: an observational study.
Rzeplinski, Radoslaw; Szymanski, Piotr; Hamer, Karolina; Zdziebko, Magdalena; Szarowska, Agnieszka; Korcz, Tomasz; Zaczynski, Artur; Król, Zbigniew; Wierzba, Waldemar.
  • Rzeplinski R; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland; Department of Descriptive and Clinical Anatomy, Medical University of Warsaw, Warsaw, Poland. radoslaw.rzeplinski@wum.edu.pl
  • Szymanski P; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  • Hamer K; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  • Zdziebko M; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  • Szarowska A; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  • Korcz T; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  • Zaczynski A; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  • Król Z; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
  • Wierzba W; Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
Pol Arch Intern Med ; 131(7-8): 679-685, 2021 08 30.
Article in English | MEDLINE | ID: covidwho-1380156
Semantic information from SemMedBD (by NLM)
1. Responsive Disease PROCESS_OF Workers
Subject
Responsive Disease
Predicate
PROCESS_OF
Object
Workers
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Anti-Antibodies PART_OF 2019 novel coronavirus
Subject
Anti-Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
4. Antigens PART_OF 2019 novel coronavirus
Subject
Antigens
Predicate
PART_OF
Object
2019 novel coronavirus
5. Workers USES Negative Results
Subject
Workers
Predicate
USES
Object
Negative Results
6. Responsive Disease PROCESS_OF Workers
Subject
Responsive Disease
Predicate
PROCESS_OF
Object
Workers
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. Anti-Antibodies PART_OF 2019 novel coronavirus
Subject
Anti-Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
9. Antigens PART_OF 2019 novel coronavirus
Subject
Antigens
Predicate
PART_OF
Object
2019 novel coronavirus
10. Workers USES Negative Results
Subject
Workers
Predicate
USES
Object
Negative Results
ABSTRACT

INTRODUCTION:

During the COVID­19 pandemic studies on workplace safety of hospital staff taking care of patients with this disease are a high priority. We decided to analyze the results of opportunistic screening for anti-SARS­CoV-2 antibodies among employees of a designated COVID-19 center.

OBJECTIVES:

The aim of the study was to investigate whether potential exposition to SARS­CoV-2 antigens is reflected in the results of serological studies. PATIENTS AND

METHODS:

Every employee who performed at least a single test between April 21 and July 20, 2020 was included in the study. The tests assessed the levels of immunoglobulin (Ig) G and IgM+IgA. Employees working in direct contact with COVID­19 patients and those participating in aerosol­generating procedures were identified.

RESULTS:

The results of 2455 tests taken by 1572 employees were analyzed. A total of 357 participants (22.7%) had at least 1 positive or equivocal result during the study period. Linear mixed models revealed gradual increases in mean levels of both IgG and IgM+IgA antibodies among employees with all negative results. The rate of change was higher among persons who had direct contact with COVID­19 patients and the highest rate of change was observed among individuals participating in aerosol­generating procedures.

CONCLUSIONS:

We detected developing humoral immune response to a new set of coronavirus antigens among the study group. It is possible that employees of designated COVID­19 centers are regularly exposed to noninfectious doses of SARS­CoV-2 or its antigens.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Pol Arch Intern Med Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Pol Arch Intern Med Year: 2021 Document Type: Article