Mast cells: Therapeutic targets for COVID-19 and beyond.
IUBMB Life
; 73(11): 1278-1292, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1380387
ABSTRACT
Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of preformed mediators residing within their secretory granules and newly synthesize a broad spectrum of inflammatory and immunomodulatory mediators. These unique features of MCs enable them to act as sentinels in response to rapid changes within their microenvironment. There is increasing evidence now that MCs play prominent roles in other pathophysiological processes besides allergic inflammation. In this review, we highlight the recent findings on the emerging roles of MCs in the pathogenesis of coronavirus disease-2019 (COVID-19) and discuss the potential of MCs as novel therapeutic targets for COVID-19 and other non-allergic inflammatory diseases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
/
Immunity, Innate
/
Mast Cells
Limits:
Animals
/
Humans
Language:
English
Journal:
IUBMB Life
Journal subject:
Molecular Biology
/
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
Iub.2552
Similar
MEDLINE
...
LILACS
LIS