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Mast cells: Therapeutic targets for COVID-19 and beyond.
Lam, Hiu Yan; Tergaonkar, Vinay; Kumar, Alan Prem; Ahn, Kwang Seok.
  • Lam HY; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
  • Tergaonkar V; Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore.
  • Kumar AP; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ahn KS; Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore.
IUBMB Life ; 73(11): 1278-1292, 2021 11.
Article in English | MEDLINE | ID: covidwho-1380387
ABSTRACT
Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of preformed mediators residing within their secretory granules and newly synthesize a broad spectrum of inflammatory and immunomodulatory mediators. These unique features of MCs enable them to act as sentinels in response to rapid changes within their microenvironment. There is increasing evidence now that MCs play prominent roles in other pathophysiological processes besides allergic inflammation. In this review, we highlight the recent findings on the emerging roles of MCs in the pathogenesis of coronavirus disease-2019 (COVID-19) and discuss the potential of MCs as novel therapeutic targets for COVID-19 and other non-allergic inflammatory diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Immunity, Innate / Mast Cells Limits: Animals / Humans Language: English Journal: IUBMB Life Journal subject: Molecular Biology / Biochemistry Year: 2021 Document Type: Article Affiliation country: Iub.2552

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Immunity, Innate / Mast Cells Limits: Animals / Humans Language: English Journal: IUBMB Life Journal subject: Molecular Biology / Biochemistry Year: 2021 Document Type: Article Affiliation country: Iub.2552