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Higher SARS-CoV-2 viral loads correlated with smaller thyroid volumes on ultrasound among male COVID-19 survivors.
Lui, David Tak Wai; Fung, Matrix Man Him; Chiu, Keith Wan Hang; Lee, Chi Ho; Chow, Wing Sun; Lee, Alan Chun Hong; Tam, Anthony Raymond; Pang, Polly; Ho, Tip Yin; Fong, Carol Ho Yi; Loong, Connie Hong Nin; Wong, Wade Wei; Lee, Cassandra Yuen Yan; Law, Chun Yiu; To, Kelvin Kai Wang; Lam, Ching Wan; Tan, Kathryn Choon Beng; Woo, Yu Cho; Hung, Ivan Fan Ngai; Lam, Karen Siu Ling; Lang, Brian Hung Hin.
  • Lui DTW; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Fung MMH; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Chiu KWH; Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China.
  • Lee CH; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Chow WS; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Lee ACH; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Tam AR; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Pang P; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Ho TY; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Fong CHY; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Loong CHN; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Wong WW; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Lee CYY; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Law CY; Division of Chemical Pathology, Queen Mary Hospital, Hong Kong, China.
  • To KKW; Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Lam CW; Department of Pathology, The University of Hong Kong, Hong Kong, China.
  • Tan KCB; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Woo YC; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Hung IFN; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Lam KSL; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  • Lang BHH; Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. blang@hku.hk.
Endocrine ; 74(2): 205-214, 2021 11.
Article in English | MEDLINE | ID: covidwho-1380484
ABSTRACT

PURPOSE:

Thyroid dysfunction, including thyroiditis, is well recognized in COVID-19 patients. We evaluated thyroid ultrasonographic features among COVID-19 survivors, which are less well known.

METHODS:

Adult COVID-19 survivors without known thyroid disorders who attended dedicated COVID-19 clinic underwent thyroid ultrasonography and assessment of thyroid function and autoimmunity. Adults admitted for acute non-thyroidal surgical problems and negative for COVID-19 were recruited as control. SARS-CoV-2 viral load (VL) was presented as the inverse of cycle threshold values from the real-time reverse transcription-polymerase chain reaction of the respiratory specimen on admission.

RESULTS:

In total, 79 COVID-19 patients and 44 non-COVID-19 controls were included. All abnormal thyroid function tests during acute COVID-19 recovered upon follow-up. Thyroid ultrasonography was performed at a median of 67 days after acute COVID-19. The median thyroid volume was 9.73 mL (IQR 7.87-13.70). In multivariable linear regression, SARS-CoV-2 VL on presentation (standardized beta -0.206, p = 0.042) inversely correlated with thyroid volume, in addition to body mass index at the time of ultrasonography (p < 0.001). Sex-specific analysis revealed similar results among men but not women. Eleven COVID-19 patients (13.9%) had ultrasonographic changes suggestive of thyroiditis, comparable to non-COVID-19 patients (p = 0.375). None of these 11 patients had isolated low thyroid-stimulating hormone levels suggestive of thyroiditis at initial admission or the time of ultrasonography.

CONCLUSIONS:

Higher SARS-CoV-2 VL on presentation were associated with smaller thyroid volumes, especially in men. Further research is suggested to investigate this possible direct viral effect of SARS-CoV-2 on the thyroid gland. There was no increased rate of ultrasonographic features suggestive of thyroiditis in COVID-19 survivors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thyroiditis / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Endocrine Journal subject: Endocrinology Year: 2021 Document Type: Article Affiliation country: S12020-021-02855-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thyroiditis / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Endocrine Journal subject: Endocrinology Year: 2021 Document Type: Article Affiliation country: S12020-021-02855-2