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Trans-ethnic genome-wide association study of severe COVID-19.
Wu, Peng; Ding, Lin; Li, Xiaodong; Liu, Siyang; Cheng, Fanjun; He, Qing; Xiao, Mingzhong; Wu, Ping; Hou, Hongyan; Jiang, Minghui; Long, Pinpin; Wang, Hao; Liu, Linlin; Qu, Minghan; Shi, Xian; Jiang, Qin; Mo, Tingting; Ding, Wencheng; Fu, Yu; Han, Shi; Huo, Xixiang; Zeng, Yingchun; Zhou, Yana; Zhang, Qing; Ke, Jia; Xu, Xi; Ni, Wei; Shao, Zuoyu; Wang, Jingzhi; Liu, Panhong; Li, Zilong; Jin, Yan; Zheng, Fang; Wang, Fang; Liu, Lei; Li, Wending; Liu, Kang; Peng, Rong; Xu, Xuedan; Lin, Yuhui; Gao, Hui; Shi, Limei; Geng, Ziyue; Mu, Xuanwen; Yan, Yu; Wang, Kai; Wu, Degang; Hao, Xingjie; Cheng, Shanshan; Qiu, Gaokun.
  • Wu P; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ding L; National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China.
  • Li X; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu S; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cheng F; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • He Q; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Xiao M; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China.
  • Wu P; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Hou H; The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.
  • Jiang M; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • Long P; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Wang H; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu L; National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China.
  • Qu M; National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China.
  • Shi X; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Jiang Q; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Mo T; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ding W; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Fu Y; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Han S; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Huo X; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zeng Y; Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
  • Zhou Y; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang Q; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ke J; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xu X; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ni W; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Shao Z; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang J; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu P; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li Z; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Jin Y; National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China.
  • Zheng F; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang F; National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China.
  • Liu L; Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
  • Li W; Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
  • Liu K; Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
  • Peng R; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • Xu X; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Lin Y; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • Gao H; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Shi L; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • Geng Z; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Mu X; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • Yan Y; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Wang K; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • Wu D; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Hao X; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
  • Cheng S; Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
  • Qiu G; Hepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Commun Biol ; 4(1): 1034, 2021 08 31.
Article in English | MEDLINE | ID: covidwho-1380915
ABSTRACT
COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild 474/667) patients of Chinese ancestry. We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. We identified three significant signals outside the well-established 3p21.31 locus an intronic variant in FOXP4-AS1 (rs1853837, odds ratio OR = 1.28, P = 2.51 × 10-10, allele frequencies in Chinese/European AF = 0.345/0.105), a frameshift insertion in ABO (rs8176719, OR = 1.19, P = 8.98 × 10-9, AF = 0.422/0.395) and a Chinese-specific intronic variant in MEF2B (rs74490654, OR = 8.73, P = 1.22 × 10-8, AF = 0.004/0). These findings highlight an important role of the adaptive immunity and the ABO blood-group system in protection from developing severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ethnicity / Genome-Wide Association Study / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Variants Limits: Humans Language: English Journal: Commun Biol Year: 2021 Document Type: Article Affiliation country: S42003-021-02549-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ethnicity / Genome-Wide Association Study / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Variants Limits: Humans Language: English Journal: Commun Biol Year: 2021 Document Type: Article Affiliation country: S42003-021-02549-5