Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19.
Sao Paulo Med J
; 140(1): 12-16, 2022.
Article
in English
| MEDLINE | ID: covidwho-1381309
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is an ongoing global health threat. However, currently, no standard therapy has been approved for the disease.OBJECTIVES:
To evaluate the clinical effectiveness of convalescent plasma (CP) in patients with acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN ANDSETTING:
Retrospective study conducted at Kayseri City Education and Research Hospital, Kayseri, Turkey.METHODS:
The case group consisted of adult patients (> 18 years) with ARDS due to COVID-19 who received CP in combination with antiviral and supportive treatment. These patients were compared with others who only received antiviral and supportive treatment.RESULTS:
During the study period, a total of 30 patients with ARDS due to COVID-19 were included. Eleven patients (36%) received CP in combination with antiviral and supportive treatment, whereas nineteen patients (64%) in the control group only received antiviral and supportive treatment. On admission, the median age, demographic and clinical data and initial laboratory test results were similar between the groups (P > 0.05). On the 14th day of treatment, the laboratory values remained similar between the groups (P > 0.05). The mortality rates were not significantly different between the groups.CONCLUSION:
CP treatment did not affect mortality or lead to clinical improvement for COVID-19 patients with ARDS.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Humans
Language:
English
Journal:
Sao Paulo Med J
Journal subject:
Medicine
Year:
2022
Document Type:
Article
Affiliation country:
1516-3180.2021.0200.R1.03052021
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