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Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease.
Bar-Meir, Maskit; Guri, Alex; Godfrey, Max E; Shack, Avram R; Hashkes, Philip J; Goldzweig, Ofra; Megged, Orli.
  • Bar-Meir M; Pediatric Infectious Diseases, Shaare-Zedek Medical Center, P.O.B 3235, 91301, Jerusalem, Israel. mbarmeir@gmail.com.
  • Guri A; The Faculty of Medicine, Hebrew University, Jerusalem, Israel. mbarmeir@gmail.com.
  • Godfrey ME; Pediatric Department, Shaare-Zedek Medical Center, Jerusalem, Israel. mbarmeir@gmail.com.
  • Shack AR; The Faculty of Medicine, Hebrew University, Jerusalem, Israel.
  • Hashkes PJ; Pediatric Department, Kaplan Medical Center, Rehovot, Israel.
  • Goldzweig O; Pediatric Department, Shaare-Zedek Medical Center, Jerusalem, Israel.
  • Megged O; Pediatric Cardiology Unit, Shaare-Zedek Medical Center, Jerusalem, Israel.
Sci Rep ; 11(1): 13840, 2021 07 05.
Article in English | MEDLINE | ID: covidwho-1383121
ABSTRACT
To characterize the new SARS-Co-V-2 related multisystem inflammatory syndrome in children (MIS-C) among Israeli children and to compare it with Kawasaki disease (KD). We compared, in two medical centers, the clinical and laboratory characteristics of MIS-C, KD and an intermediate group, which met the case definitions of both conditions. MIS-C patients were older, were more likely to be hypotensive, to have significant gastrointestinal symptoms, lymphopenia and thrombocytopenia and to have non-coronary abnormal findings in their echocardiogram. Lymphopenia was an independent predictor of MIS-C. Most of our MIS-C patients responded promptly to corticosteroid therapy. KD incidence in both centers was similar in 2019 and 2020. Although there is clinical overlap between KD and MIS-C, these are separate entities. Lymphopenia clearly differentiates between these entities. MIS-C patients may benefit from corticosteroids as first-line therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 / Lymphopenia / Mucocutaneous Lymph Node Syndrome Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Young adult Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-93389-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 / Lymphopenia / Mucocutaneous Lymph Node Syndrome Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Young adult Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-93389-0