First case of low-dose umbilical cord blood therapy for pediatric acute respiratory distress syndrome induced by Pneumocystis carinii pneumonia.
Eur J Med Res
; 26(1): 100, 2021 Aug 28.
Article
in English
| MEDLINE | ID: covidwho-1383682
ABSTRACT
OBJECTIVE:
This study aimed to present the case of a boy with acute distress syndrome (ARDS) treated with low-dose umbilical cord blood (UCB) therapy and explore the underlying possible mechanism.METHODS:
A 7-year-old boy with severe Pneumocystis carinii pneumonia and severe ARDS was treated with allogeneic UCB as salvage therapy.RESULTS:
The patient did not improve after being treated with lung protective ventilation, pulmonary surfactant replacement, and extracorporeal membrane oxygenation (ECMO) for 30 days. However, his disease reversed 5 days after allogeneic UCB infusion, and he weaned from ECMO after 7 days of infusion. Bioinformatics confirmed that his Toll-like receptor (TLR) was abnormal before UCB infusion. However, after the infusion, his immune system was activated and repaired, and the TLR4/MyD88/NF-κB signaling pathway was recovered.CONCLUSION:
Allogenic UCB could treat ARDS by repairing the TLR4/MyD88/NF-κB signaling pathway, thereby achieving stability of the immune system.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Pneumocystis
/
Respiratory Distress Syndrome
/
Extracorporeal Membrane Oxygenation
/
Cord Blood Stem Cell Transplantation
/
Pneumocystis carinii
/
Fetal Blood
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Child
/
Humans
/
Male
Language:
English
Journal:
Eur J Med Res
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
S40001-021-00548-0
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