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A parsimonious approach for recognizing SARS-CoV-2 and host interactions.
Ganguly, Bhaskar.
  • Ganguly B; Department of Clinical Research, Research and Development Division, Ayurvet Limited, Baddi, Himachal Pradesh, India.
J Med Virol ; 93(7): 4576-4584, 2021 07.
Article in English | MEDLINE | ID: covidwho-1384233
ABSTRACT
Effective countermeasures against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) demand a better understanding of the pathogen-host interactions. However, such information about the targets, responses, and effects in the host due to the virus is limited, especially so in the case of newly emerged pathogens. The peptide domains that form the interfaces of host and pathogen interacting proteins being evolutionarily conserved, it may be hypothesized that such interactions can be inferred from the similarities in the nucleotide sequences between the host and the pathogen. This communication reports the results of a study based on a parsimonious approach for the identification of the host-virus interactions, where sequence complementarity between the human and SARS-Cov-2 genomes was used to predict several interactions between the host and SARS-CoV-2 at different levels of biological organization. In particular, the findings are suggestive of a direct effect of SARS-CoV-2 on cardiac health. The existing literature on host responses to SARS-CoV-2 and other viruses attest to many of these predicted interactions, supporting the utility of the proposed approach for the identification of host interactions with other novel pathogens.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Genome, Human / Genome, Viral / Host-Pathogen Interactions / SARS-CoV-2 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: JMV.26824

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Genome, Human / Genome, Viral / Host-Pathogen Interactions / SARS-CoV-2 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: JMV.26824