Clinical and laboratory factors associated with coronavirus disease 2019 (Covid-19): A systematic review and meta-analysis.
Rev Med Virol
; 31(6): e2288, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1384306
ABSTRACT
SARS Coronavirus-2 is one of the most widespread viruses globally during the 21st century, whose severity and ability to cause severe pneumonia and death vary. We performed a comprehensive systematic review of all studies that met our standardised criteria and then extracted data on the age, symptoms, and different treatments of Covid-19 patients and the prognosis of this disease during follow-up. Cases in this study were divided according to severity and death status and meta-analysed separately using raw mean and single proportion methods. We included 171 complete studies including 62,909 confirmed cases of Covid-19, of which 148 studies were meta-analysed. Symptoms clearly emerged in an escalating manner from mild-moderate symptoms, pneumonia, severe-critical to the group of non-survivors. Hypertension (Pooled proportion (PP) 0.48 [95% Confident interval (CI) 0.35-0.61]), diabetes (PP 0.23 [95% CI 0.16-0.33]) and smoking (PP 0.12 [95% CI 0.03-0.38]) were highest regarding pre-infection comorbidities in the non-survivor group. While acute respiratory distress syndrome (PP 0.49 [95% CI 0.29-0.78]), (PP 0.63 [95% CI 0.34-0.97]) remained one of the most common complications in the severe and death group respectively. Bilateral ground-glass opacification (PP 0.68 [95% CI 0.59-0.75]) was the most visible radiological image. The mortality rates estimated (PP 0.11 [95% CI 0.06-0.19]), (PP 0.03 [95% CI 0.01-0.05]), and (PP 0.01 [95% CI 0-0.3]) in severe-critical, pneumonia and mild-moderate groups respectively. This study can serve as a high evidence guideline for different clinical presentations of Covid-19, graded from mild to severe, and for special forms like pneumonia and death groups.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cough
/
Dyspnea
/
Fatigue
/
Fever
/
SARS-CoV-2
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Rev Med Virol
Journal subject:
Virology
Year:
2021
Document Type:
Article
Affiliation country:
Rmv.2288
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