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Clinical and laboratory factors associated with coronavirus disease 2019 (Covid-19): A systematic review and meta-analysis.
Minh, Le Huu Nhat; Abozaid, Ali Ahmed-Fouad; Ha, Nam Xuan; Le Quang, Loc; Gad, Abdelrahman Gamil; Tiwari, Ranjit; Nhat-Le, Tran; Quyen, Dinh Kim; Al-Manaseer, Balqees; Kien, Nguyen Dang; Vuong, Nguyen Lam; Zayan, Ahmad Helmy; Nhi, Le Huu Hanh; Surya Dila, Kadek Agus; Varney, Joseph; Tien Huy, Nguyen.
  • Minh LHN; Cardiovascular Research Department, Methodist Hospital, Merrillville, Indiana, USA.
  • Abozaid AA; Online Research Club, Nagasaki, Japan.
  • Ha NX; Online Research Club, Nagasaki, Japan.
  • Le Quang L; Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Gad AG; Online Research Club, Nagasaki, Japan.
  • Tiwari R; Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
  • Nhat-Le T; Online Research Club, Nagasaki, Japan.
  • Quyen DK; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  • Al-Manaseer B; Online Research Club, Nagasaki, Japan.
  • Kien ND; Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Vuong NL; Online Research Club, Nagasaki, Japan.
  • Zayan AH; Department of Internal Medicine, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
  • Nhi LHH; Online Research Club, Nagasaki, Japan.
  • Surya Dila KA; Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
  • Varney J; Online Research Club, Nagasaki, Japan.
  • Tien Huy N; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Rev Med Virol ; 31(6): e2288, 2021 11.
Article in English | MEDLINE | ID: covidwho-1384306
ABSTRACT
SARS Coronavirus-2 is one of the most widespread viruses globally during the 21st century, whose severity and ability to cause severe pneumonia and death vary. We performed a comprehensive systematic review of all studies that met our standardised criteria and then extracted data on the age, symptoms, and different treatments of Covid-19 patients and the prognosis of this disease during follow-up. Cases in this study were divided according to severity and death status and meta-analysed separately using raw mean and single proportion methods. We included 171 complete studies including 62,909 confirmed cases of Covid-19, of which 148 studies were meta-analysed. Symptoms clearly emerged in an escalating manner from mild-moderate symptoms, pneumonia, severe-critical to the group of non-survivors. Hypertension (Pooled proportion (PP) 0.48 [95% Confident interval (CI) 0.35-0.61]), diabetes (PP 0.23 [95% CI 0.16-0.33]) and smoking (PP 0.12 [95% CI 0.03-0.38]) were highest regarding pre-infection comorbidities in the non-survivor group. While acute respiratory distress syndrome (PP 0.49 [95% CI 0.29-0.78]), (PP 0.63 [95% CI 0.34-0.97]) remained one of the most common complications in the severe and death group respectively. Bilateral ground-glass opacification (PP 0.68 [95% CI 0.59-0.75]) was the most visible radiological image. The mortality rates estimated (PP 0.11 [95% CI 0.06-0.19]), (PP 0.03 [95% CI 0.01-0.05]), and (PP 0.01 [95% CI 0-0.3]) in severe-critical, pneumonia and mild-moderate groups respectively. This study can serve as a high evidence guideline for different clinical presentations of Covid-19, graded from mild to severe, and for special forms like pneumonia and death groups.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cough / Dyspnea / Fatigue / Fever / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Clinical Practice Guide / Prognostic study / Randomized controlled trials / Reviews / Risk factors / Systematic review Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2288

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cough / Dyspnea / Fatigue / Fever / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Clinical Practice Guide / Prognostic study / Randomized controlled trials / Reviews / Risk factors / Systematic review Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2288