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Toxicology and pharmacology of synthetic organoselenium compounds: an update.
Nogueira, Cristina W; Barbosa, Nilda V; Rocha, João B T.
  • Nogueira CW; Laboratório de Síntese, Reatividade e Avaliação Farmacológica E Toxicológica de Organocalcogênios, Centro de Ciências Naturais E Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil. criswn@ufsm.br.
  • Barbosa NV; Laboratório de Síntese, Reatividade e Avaliação Farmacológica E Toxicológica de Organocalcogênios, Centro de Ciências Naturais E Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil.
  • Rocha JBT; Laboratório de Síntese, Reatividade e Avaliação Farmacológica E Toxicológica de Organocalcogênios, Centro de Ciências Naturais E Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil. jbtrocha@yahoo.com.br.
Arch Toxicol ; 95(4): 1179-1226, 2021 04.
Article in English | MEDLINE | ID: covidwho-1384375
Semantic information from SemMedBD (by NLM)
1. Anti-Inflammatory Agents STIMULATES TRANSCRIPTION FACTOR
Subject
Anti-Inflammatory Agents
Predicate
STIMULATES
Object
TRANSCRIPTION FACTOR
2. TRANSCRIPTION FACTOR INTERACTS_WITH Antioxidants
Subject
TRANSCRIPTION FACTOR
Predicate
INTERACTS_WITH
Object
Antioxidants
3. Organoselenium Compounds STIMULATES Antioxidants
Subject
Organoselenium Compounds
Predicate
STIMULATES
Object
Antioxidants
4. Peptide Hydrolases PART_OF 2019 novel coronavirus
Subject
Peptide Hydrolases
Predicate
PART_OF
Object
2019 novel coronavirus
5. Inhibitor PART_OF Peptide Hydrolases
Subject
Inhibitor
Predicate
PART_OF
Object
Peptide Hydrolases
6. Anti-Inflammatory Agents STIMULATES TRANSCRIPTION FACTOR
Subject
Anti-Inflammatory Agents
Predicate
STIMULATES
Object
TRANSCRIPTION FACTOR
7. TRANSCRIPTION FACTOR INTERACTS_WITH Antioxidants
Subject
TRANSCRIPTION FACTOR
Predicate
INTERACTS_WITH
Object
Antioxidants
8. Organoselenium Compounds STIMULATES Antioxidants
Subject
Organoselenium Compounds
Predicate
STIMULATES
Object
Antioxidants
9. Peptide Hydrolases PART_OF 2019 novel coronavirus
Subject
Peptide Hydrolases
Predicate
PART_OF
Object
2019 novel coronavirus
10. Inhibitor PART_OF Peptide Hydrolases
Subject
Inhibitor
Predicate
PART_OF
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Peptide Hydrolases
ABSTRACT
Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of selenium as a tool in organic synthesis and as a pharmacological agent goes back to the middle of the nineteenth and the beginning of the twentieth centuries. The rediscovery of ebselen and its investigation in clinical trials have motivated the search for new organoselenium molecules with pharmacological properties. Although ebselen and diselenides have some overlapping pharmacological properties, their molecular targets are not identical. However, they have similar anti-inflammatory and antioxidant activities, possibly, via activation of transcription factors, regulating the expression of antioxidant genes. In short, our knowledge about the pharmacological properties of simple organoselenium compounds is still elusive. However, contrary to our early expectations that they could imitate selenoproteins, organoselenium compounds seem to have non-specific modulatory activation of antioxidant pathways and specific inhibitory effects in some thiol-containing proteins. The thiol-oxidizing properties of organoselenium compounds are considered the molecular basis of their chronic toxicity; however, the acute use of organoselenium compounds as inhibitors of specific thiol-containing enzymes can be of therapeutic significance. In summary, the outcomes of the clinical trials of ebselen as a mimetic of lithium or as an inhibitor of SARS-CoV-2 proteases will be important to the field of organoselenium synthesis. The development of computational techniques that could predict rational modifications in the structure of organoselenium compounds to increase their specificity is required to construct a library of thiol-modifying agents with selectivity toward specific target proteins.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organoselenium Compounds Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Arch Toxicol Year: 2021 Document Type: Article Affiliation country: S00204-021-03003-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organoselenium Compounds Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Arch Toxicol Year: 2021 Document Type: Article Affiliation country: S00204-021-03003-5