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SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts.
Essahib, Wafaa; Verheyen, Greta; Tournaye, Herman; Van de Velde, Hilde.
  • Essahib W; Research Group Reproduction and Immunology (REIM), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussel, Belgium.
  • Verheyen G; Center for Reproductive Medicine (CRG), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090, Brussel, Belgium.
  • Tournaye H; Center for Reproductive Medicine (CRG), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090, Brussel, Belgium.
  • Van de Velde H; Center for Reproductive Medicine (CRG), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090, Brussel, Belgium. hilde.vandevelde@uzbrussel.be.
J Assist Reprod Genet ; 37(11): 2657-2660, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-1384515
ABSTRACT

PURPOSE:

To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts.

METHODS:

Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research.

RESULTS:

SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma.

CONCLUSION:

Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oocytes / Blastocyst / Peptidyl-Dipeptidase A / Basigin Type of study: Experimental Studies Limits: Female / Humans Language: English Journal: J Assist Reprod Genet Journal subject: Genetics / Reproductive Medicine Year: 2020 Document Type: Article Affiliation country: S10815-020-01952-X

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oocytes / Blastocyst / Peptidyl-Dipeptidase A / Basigin Type of study: Experimental Studies Limits: Female / Humans Language: English Journal: J Assist Reprod Genet Journal subject: Genetics / Reproductive Medicine Year: 2020 Document Type: Article Affiliation country: S10815-020-01952-X