SARS-CoV-PLpro-Inhibitoren als mögliche Breitspektrum-Virostatika.
Biospektrum (Heidelb)
; 27(3): 254-256, 2021.
Article
in German
| MEDLINE | ID: covidwho-1384644
ABSTRACT
The SARS-CoV-encoded papain-like cysteine protease (PLpro) plays crucial roles in viral replication and maturation processes. It is required to cleave the precursor polyproteins into functional proteins. Thus, it is considered to be a promising target for developing specific drugs. For rational optimization of hit compounds, information about the structure-activity relationship (SAR) is fundamental. Herein, we characterize isoindolines as a new class of PLpro inhibitors.
Full text:
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Database:
MEDLINE
Language:
German
Journal:
Biospektrum (Heidelb)
Year:
2021
Document Type:
Article
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