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Antiviral activities of flavonoids.
Badshah, Syed Lal; Faisal, Shah; Muhammad, Akhtar; Poulson, Benjamin Gabriel; Emwas, Abdul Hamid; Jaremko, Mariusz.
  • Badshah SL; Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan. Electronic address: sbadshah@icp.edu.pk.
  • Faisal S; Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan.
  • Muhammad A; Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan.
  • Poulson BG; Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
  • Emwas AH; Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
  • Jaremko M; Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. Electronic address: mariusz.jaremko@kaust.edu.sa.
Biomed Pharmacother ; 140: 111596, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1385083
ABSTRACT
Flavonoids are natural phytochemicals known for their antiviral activity. The flavonoids acts at different stages of viral infection, such as viral entrance, replication and translation of proteins. Viruses cause various diseases such as SARS, Hepatitis, AIDS, Flu, Herpes, etc. These, and many more viral diseases, are prevalent in the world, and some (i.e. SARS-CoV-2) are causing global chaos. Despite much struggle, effective treatments for these viral diseases are not available. The flavonoid class of phytochemicals has a vast number of medicinally active compounds, many of which are studied for their potential antiviral activity against different DNA and RNA viruses. Here, we reviewed many flavonoids that showed antiviral activities in different testing environments such as in vitro, in vivo (mice model) and in silico. Some flavonoids had stronger inhibitory activities, showed no toxicity & the cell proliferation at the tested doses are not affected. Some of the flavonoids used in the in vivo studies also protected the tested mice prophylactically from lethal doses of virus, and effectively prevented viral infection. The glycosides of some of the flavonoids increased the solubility of some flavonoids, and therefore showed increased antiviral activity as compared to the non-glycoside form of that flavonoid. These phytochemicals are active against different disease-causing viruses, and inhibited the viruses by targeting the viral infections at multiple stages. Some of the flavonoids showed more potent antiviral activity than the market available drugs used to treat viral infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viruses / Flavonoids / Virus Diseases Limits: Animals / Humans Language: English Journal: Biomed Pharmacother Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viruses / Flavonoids / Virus Diseases Limits: Animals / Humans Language: English Journal: Biomed Pharmacother Year: 2021 Document Type: Article