A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection.

Casanova, Jean-Laurent; Su, Helen C

Casanova, Jean-Laurent; Su, Helen C.

Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller Unversity, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. Electronic address: casanova@rockefelle
Su HC; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Cell ; 181(6): 1194-1199, 2020 06 11.

Article in English | MEDLINE | ID: covidwho-1385209

ABSTRACT

ABSTRACT

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

Subject(s)

Coronavirus Infections/genetics; Coronavirus Infections/immunology; Genetic Predisposition to Disease; Pneumonia, Viral/genetics; Pneumonia, Viral/immunology; Age Factors; Betacoronavirus/physiology; COVID-19; Coronavirus Infections/epidemiology; Coronavirus Infections/physiopathology; Disease Resistance; Genetic Association Studies; Genetic Diseases, Inborn/immunology; Genetic Variation; Genome, Human; Host-Pathogen Interactions; Humans; Infections/genetics; Infections/immunology; Infections/physiopathology; Pandemics; Pneumonia, Viral/epidemiology; Pneumonia, Viral/physiopathology; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Genetic Predisposition to Disease Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Cell Year: 2020 Document Type: Article

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