BASELINE CHARACTERISTICS AND MORTALITY IN PATIENTS WITH SARS-COV-2 CONFIRMED INFECTION: SINGLE MAJOR ACADEMIC CENTER EXPERIENCE

ABSTRACT

SESSION TITLE Respiratory Infections What have We Learned About COVID-19 and New Trial Data for Management of Aspergilloma SESSION TYPE Original Investigations PRESENTED ON October 18-21, 2020 PURPOSE: Previous studies have shown that demographics, baseline characteristics and comorbidities may play an important role in the outcomes of patients diagnosed with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Older patients, and those with respiratory or cardiovascular conditions, appear to be at greater risk for severe complications. We aim to describe baseline characteristics and mortality in patients with confirmed SARS-CoV-2 infection at our institution. METHOD(S) Retrospective medical records review of patients diagnosed with SARS-CoV-2 between January 1, 2020 and May 8, 2019 at Beth Israel Deaconess Medical Center, Boston MA. Patients were identified from our institutional database (Clinical Query 2). Demographics, baseline comorbidities, medications at admission and initial laboratories results were collected. Clinical outcomes such as mortality, ICU admission and mechanical ventilation were also recorded. RESULT(S) A total of 449 subjects were included (Age 57 years [IQR 41-69];BMI 30.2 kg/m [IQR 25.9-35.3];44.5% males). One hundred-fifteen patients (25.6%) required hospital admission with a median hospital stay of 6 days (IQR 3-12). From those, 28 patients (24.35 %) required ICU management with a median stay of 9 days (4-15.5). Seventeen subjects (14.78%) required mechanical ventilation with a mean time for of 10.65 days (SD 7.84). From the intubated patients, 2 (11.74%) ended up with tracheostomy. Twenty-nine (6.46%) of the total died due to SARS-CoV-2 complications. Elderly (82 vs 55 years, p=<0.001), smokers (37.9% vs 14.8%, p=0.003), congestive heart failure (31% vs 11%, p=0.004), dementia (24.1% vs 4%, p=<0.001), diabetes mellitus (44.8% vs 26.2%, p=0.05), chronic kidney disease (62.1% vs 13.6%, p=<0.001) and cancer patients (20.7% vs 7.9%, p=0.042) died more frequently due to SARS-CoV-2 related complications. Mortality for patients requiring ICU admission was 37.9% compared 4% (p=<0.001). For patient requiring mechanical ventilation, mortality was 24.1% compared to 2.4% (p=<0.001). CONCLUSION(S) Our review showed that elderly, presence of comorbidities, ICU admission and patient requiring mechanical ventilation died more frequently due to SARS-CoV-2 related complications. CLINICAL IMPLICATIONS Impact of baseline characteristics and comorbid conditions in the outcomes of patients diagnosed with SARS-CoV-2 infection. DISCLOSURES No relevant relationships by Ramsy Abdelghani, source=Web Response No relevant relationships by Alvaro Ayala, source=Web Response No relevant relationships by Alex Chee, source=Web Response No relevant relationships by Fayez Kheir, source=Web Response Consultant relationship with Boston Scientific Please note $1001 - $5000 by Adnan Majid, source=Web Response, value=Consulting fee Consultant relationship with olympus Please note $5001 - $20000 by Adnan Majid, source=Web Response, value=Consulting fee Consultant relationship with pinacle biologics Please note $1001 - $5000 by Adnan Majid, source=Web Response, value=Consulting fee Consultant relationship with cook medical Please note $1001 - $5000 by Adnan Majid, source=Web Response, value=Consulting fee No relevant relationships by Mihir Parikh, source=Web Response No relevant relationships by Priya Patel, source=Web Response No relevant relationships by Juan Pablo Uribe, source=Web ResponseCopyright © 2020 American College of Chest Physicians