Your browser doesn't support javascript.
Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities.
Shen, Xiao Bao; Chen, Xing; Zhang, Zhao Yan; Wu, Fu Fang; Liu, Xin Hua.
  • Shen XB; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, 236037, PR China.
  • Chen X; School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
  • Zhang ZY; School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
  • Wu FF; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, 236037, PR China. Electronic address: fufang_wu@foxmail.com.
  • Liu XH; Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang, 236037, PR China; School of Pharmacy, Anhui Medical University, Hefei, 230032, China. Electronic address: xhliuhx@163.com.
Eur J Med Chem ; 225: 113818, 2021 Dec 05.
Article in English | MEDLINE | ID: covidwho-1385491
ABSTRACT
Cathepsin C, an important lysosomal cysteine protease, mediates the maturation process of neutrophil serine proteases, and participates in the inflammation and immune regulation process associated with polymorphonuclear neutrophils. Therefore, cathepsin C is considered to be an attractive target for treating inflammatory diseases. With INS1007 (trade name brensocatib) being granted a breakthrough drug designation by FDA for the treatment of Adult Non-cystic Fibrosis Bronchiectasis and Coronavirus Disease 2019, the development of cathepsin C inhibitor will attract attentions from medicinal chemists in the future soon. Here, we summarized the research results of cathepsin C as a therapeutic target, focusing on the development of cathepsin C inhibitor, and provided guidance and reference opinions for the upcoming development boom of cathepsin C inhibitor.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Protease Inhibitors / Cathepsin C / Drug Discovery / Anti-Inflammatory Agents Limits: Humans Language: English Journal: Eur J Med Chem Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Protease Inhibitors / Cathepsin C / Drug Discovery / Anti-Inflammatory Agents Limits: Humans Language: English Journal: Eur J Med Chem Year: 2021 Document Type: Article