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Low impact of SARS-CoV-2 infection among paediatric acute respiratory disease hospitalizations.
Melé, Maria; Henares, Desiree; Pino, Rosa; Asenjo, Silvia; Matamoros, Rocío; Fumadó, Victoria; Fortuny, Claudia; García-García, Juan-José; Jordan, Iolanda; Brotons, Pedro; Muñoz-Almagro, Carmen; de-Sevilla, Mariona-Fernández; Launes, Cristian.
  • Melé M; Paediatrics Department, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain.
  • Henares D; Molecular Microbiology Department, HSJD, Barcelona, Spain.
  • Pino R; Paediatrics Department, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain.
  • Asenjo S; Paediatrics Department, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain.
  • Matamoros R; Paediatrics Department, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain.
  • Fumadó V; Paediatric Infectious Diseases Department, HSJD, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
  • Fortuny C; Paediatric Infectious Diseases Department, HSJD, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • García-García JJ; Paediatrics Department, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Jordan I; University of Barcelona, Barcelona, Spain; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Paediatric Intensive Care Unit, HSJD, Barcelona, Spain.
  • Brotons P; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Paediatric Intensive Care Unit, HSJD, Barcelona, Spain.
  • Muñoz-Almagro C; Molecular Microbiology Department, HSJD, Barcelona, Spain; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Universitat Internacional de Catalunya, Barcelona, Spain.
  • de-Sevilla MF; Paediatrics Department, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Launes C; Paediatrics Department, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic
J Infect ; 82(3): 414-451, 2021 03.
Article in English | MEDLINE | ID: covidwho-1386002
Semantic information from SemMedBD (by NLM)
1. Acute respiratory disease PROCESS_OF Patients
Subject
Acute respiratory disease
Predicate
PROCESS_OF
Object
Patients
2. Bronchiolitis PROCESS_OF Infant
Subject
Bronchiolitis
Predicate
PROCESS_OF
Object
Infant
3. 2019 novel coronavirus LOCATION_OF creatinine
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
creatinine
4. Pneumonia PROCESS_OF Child
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Child
5. Acute respiratory disease PROCESS_OF Patients
Subject
Acute respiratory disease
Predicate
PROCESS_OF
Object
Patients
6. Bronchiolitis PROCESS_OF Infant
Subject
Bronchiolitis
Predicate
PROCESS_OF
Object
Infant
7. 2019 novel coronavirus LOCATION_OF creatinine
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
creatinine
8. Pneumonia PROCESS_OF Child
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Child
ABSTRACT

OBJECTIVE:

This study describes the characteristics of children requiring admission with an acute lower-respiratory disease (ALRD) during the SARS-CoV-2 pandemics.

METHODS:

Epidemiological, clinical, and microbiological data from patients with ALRD (pneumonia, bronchiolitis, bronchospasm) admitted to a reference paediatric hospital in Spain during the pandemic peak (week 11-20/2020) were prospectively analysed.

RESULTS:

110 patients were included. 7 were SARS-CoV-2(+) and they were older in comparison to SARS-CoV-2(-). Among SARS-CoV-2(+) patients, pneumonia was the main clinical diagnosis (6/7) and bronchospasm was absent. Only 1 of 29 infants diagnosed with bronchiolitis was SARS-CoV-2(+). Lower values of leucocytes, lymphocytes, neutrophils, and platelets and higher values of creatinine were found in SARS-CoV-2(+). Human-rhinovirus/enterovirus was the main detection (11/32). There were not differences in PICU admission rates between SARS-CoV-2(+) and (-).

CONCLUSIONS:

Most of the ALRD episodes identified during the pandemics were not related to SARS-CoV-2 infection. SARS-CoV-2 was mainly found causing pneumonia in older children.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Child / Humans / Infant Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.JINF.2020.10.013

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Child / Humans / Infant Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.JINF.2020.10.013