Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale.

Bird, Paul William; Holmes, Christopher; Fletcher, Oliver; Badhwar, Vinay; Toovey, Oliver; Tang, Julian Wei-Tze

Bird, Paul William; Holmes, Christopher; Fletcher, Oliver; Badhwar, Vinay; Toovey, Oliver; Tang, Julian Wei-Tze.

Bird PW; Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, LE1 5WW Leicester, United Kingdom. Electronic address: julian.tang@uhl-tr.nhs.uk.
Holmes C; Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, LE1 5WW Leicester, United Kingdom; Respiratory Sciences, University of Leicester, LE1 9HN, United Kingdom.
Fletcher O; Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, LE1 5WW Leicester, United Kingdom.
Badhwar V; Intensive Care Unit, University Hospitals of Leicester NHS Trust, Leicester, Royal Infirmary, LE1 5WW Leicester, United Kingdom.
Toovey O; Clinical Virology, University Hospitals 24 of Leicester NHS Trust, Leicester, Royal Infirmary, LE1 5WW Leicester, United Kingdom.
Tang JW; Respiratory Sciences, University of Leicester, LE1 9HN, United Kingdom.

J Infect ; 83(1): 119-145, 2021 07.

Article in English | MEDLINE | ID: covidwho-1386031

ABSTRACT

ABSTRACT

We performed a retrospective screening of 428 serum samples for anti-SARS-CoV-2 immunoglobulin during a period of low prevalence. Employing two different serological tests yielded discrepant results for 10 samples; highlighting an increased risk of potential false positive results and the need for further confirmatory testing before publication of data.

Subject(s)

COVID-19; SARS-CoV-2; Brazil; False Positive Reactions; Humans; Immunoglobulins; Prevalence; Retrospective Studies; Sensitivity and Specificity

Keywords

Low prevalence; SARS-CoV-2; Serological testing

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: J Infect Year: 2021 Document Type: Article

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