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Deceiving SARS-CoV-2 molecular-tropism clues - A combinational contemporary strategy.
Balaji, Apb; Bhuvaneswari, Srinivasan; Kumar, D Nanda.
  • Balaji A; Vanta Bioscience Limited, Gummidipoondi, Tamil Nadu, India; Ecoysus Life Science, Chennai, Tamil Nadu, India. Electronic address: balaji.apb15@gmail.com.
  • Bhuvaneswari S; Ecoysus Life Science, Chennai, Tamil Nadu, India; Department of Biotechnology, Anna University, Chennai, Tamil Nadu, India. Electronic address: mybiotech09@gmail.com.
  • Kumar DN; Ecoysus Life Science, Chennai, Tamil Nadu, India. Electronic address: d.nandamsc@gmail.com.
Med Hypotheses ; 144: 109976, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-1386300
ABSTRACT
Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 frompreponetargets. (b) Remedy As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificialsurfactantsystem as a remedy to pulmonary complications. (c) Conveyor We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Pulmonary Surfactants / Erythrocytes / Viral Tropism / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Pulmonary Surfactants / Erythrocytes / Viral Tropism / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article