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Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality.
Macias-Verde, David; Lara, Pedro C; Burgos-Burgos, Javier.
  • Macias-Verde D; Oncology Department, Hospitales Universitarios San Roque, Las Palmas, GC, Spain. Electronic address: david.macias@hospitalessanroque.com.
  • Lara PC; Oncology Department, Hospitales Universitarios San Roque, Las Palmas, GC, Spain; Universidad Fernando Pessoa Canarias, Las Palmas, GC, Spain; Instituto Canario de Investigación del Cáncer, Tenerife, Spain.
  • Burgos-Burgos J; Oncology Department, Hospitales Universitarios San Roque, Las Palmas, GC, Spain.
Med Hypotheses ; 146: 110396, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1386308
ABSTRACT
We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Climate Change / Air Pollution, Radioactive / NLR Family, Pyrin Domain-Containing 3 Protein / SARS-CoV-2 / COVID-19 / Inflammation Subject: Climate Change / Air Pollution, Radioactive / NLR Family, Pyrin Domain-Containing 3 Protein / SARS-CoV-2 / COVID-19 / Inflammation Language: English Journal: Med Hypotheses Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Climate Change / Air Pollution, Radioactive / NLR Family, Pyrin Domain-Containing 3 Protein / SARS-CoV-2 / COVID-19 / Inflammation Subject: Climate Change / Air Pollution, Radioactive / NLR Family, Pyrin Domain-Containing 3 Protein / SARS-CoV-2 / COVID-19 / Inflammation Language: English Journal: Med Hypotheses Clinical aspect: Etiology Year: 2021
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