SARS-CoV-2 viral RNA levels are not 'viral load'.
Trends Microbiol
; 29(11): 970-972, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1386663
ABSTRACT
Ct values are commonly used as proxies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 'viral load'. Since coronaviruses are positive single-stranded RNA [(+)ssRNA] viruses, current reverse transcription (RT)-qPCR target amplification does not distinguish replicative from transcriptional RNA. Although analyses of Ct values remain informative, equating them with viral load may lead to flawed conclusions as it is presently unknown whether (and to what extent) variation in Ct reflects variation in viral load or in gene expression.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Viral
/
Viral Load
/
SARS-CoV-2
/
COVID-19
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Trends Microbiol
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS