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The evolution and future of influenza pandemic preparedness.
Harrington, Walter N; Kackos, Christina M; Webby, Richard J.
  • Harrington WN; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Kackos CM; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Webby RJ; St. Jude Children's Research Hospital, Graduate School of Biomedical Sciences, Memphis, TN, USA.
Exp Mol Med ; 53(5): 737-749, 2021 05.
Article in English | MEDLINE | ID: covidwho-1387171
ABSTRACT
The influenza virus is a global threat to human health causing unpredictable yet recurring pandemics, the last four emerging over the course of a hundred years. As our knowledge of influenza virus evolution, distribution, and transmission has increased, paths to pandemic preparedness have become apparent. In the 1950s, the World Health Organization (WHO) established a global influenza surveillance network that is now composed of institutions in 122 member states. This and other surveillance networks monitor circulating influenza strains in humans and animal reservoirs and are primed to detect influenza strains with pandemic potential. Both the United States Centers for Disease Control and Prevention and the WHO have also developed pandemic risk assessment tools that evaluate specific aspects of emerging influenza strains to develop a systematic process of determining research and funding priorities according to the risk of emergence and potential impact. Here, we review the history of influenza pandemic preparedness and the current state of preparedness, and we propose additional measures for improvement. We also comment on the intersection between the influenza pandemic preparedness network and the current SARS-CoV-2 crisis. We must continually evaluate and revise our risk assessment and pandemic preparedness plans and incorporate new information gathered from research and global crises.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human Type of study: Experimental Studies / Observational study / Prognostic study / Systematic review/Meta Analysis Limits: Animals / Humans Language: English Journal: Exp Mol Med Journal subject: Molecular Biology / Biochemistry Year: 2021 Document Type: Article Affiliation country: S12276-021-00603-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human Type of study: Experimental Studies / Observational study / Prognostic study / Systematic review/Meta Analysis Limits: Animals / Humans Language: English Journal: Exp Mol Med Journal subject: Molecular Biology / Biochemistry Year: 2021 Document Type: Article Affiliation country: S12276-021-00603-0