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Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein.
Yang, Chan; Pan, Xiaoyan; Xu, Xinfeng; Cheng, Chen; Huang, Yuan; Li, Lin; Jiang, Shibo; Xu, Wei; Xiao, Gengfu; Liu, Shuwen.
  • Yang C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Pan X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
  • Xu X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Cheng C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Huang Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Li L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan-Jinbo Joint Research Center, Fudan University, Shanghai, China.
  • Xu W; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. xuwei3322@smu.edu.cn.
  • Xiao G; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. xiaogf@wh.iov.cn.
  • Liu S; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. liusw@smu.edu.cn.
Signal Transduct Target Ther ; 5(1): 220, 2020 10 06.
Article in English | MEDLINE | ID: covidwho-1387194
Semantic information from SemMedBD (by NLM)
1. salvianolic acid C DISRUPTS Severe Acute Respiratory Syndrome
Subject
salvianolic acid C
Predicate
DISRUPTS
Object
Severe Acute Respiratory Syndrome
2. salvianolic acid C DISRUPTS Severe Acute Respiratory Syndrome
Subject
salvianolic acid C
Predicate
DISRUPTS
Object
Severe Acute Respiratory Syndrome

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Protein Subunits / Alkenes / Virus Internalization / Polyphenols / Spike Glycoprotein, Coronavirus / Betacoronavirus Language: English Journal: Signal Transduct Target Ther Year: 2020 Document Type: Article Affiliation country: S41392-020-00325-1

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Protein Subunits / Alkenes / Virus Internalization / Polyphenols / Spike Glycoprotein, Coronavirus / Betacoronavirus Language: English Journal: Signal Transduct Target Ther Year: 2020 Document Type: Article Affiliation country: S41392-020-00325-1