A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2.

Zhang, Zhe-Rui; Zhang, Ya-Nan; Li, Xiao-Dan; Zhang, Hong-Qing; Xiao, Shu-Qi; Deng, Fei; Yuan, Zhi-Ming; Ye, Han-Qing; Zhang, Bo

Zhang, Zhe-Rui; Zhang, Ya-Nan; Li, Xiao-Dan; Zhang, Hong-Qing; Xiao, Shu-Qi; Deng, Fei; Yuan, Zhi-Ming; Ye, Han-Qing; Zhang, Bo.

Zhang ZR; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.
Zhang YN; University of Chinese Academy of Sciences, 100049, Beijing, China.
Li XD; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.
Zhang HQ; University of Chinese Academy of Sciences, 100049, Beijing, China.
Xiao SQ; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.
Deng F; Hunan Normal University, School of Medicine, 410081, Changsha, China.
Yuan ZM; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.
Ye HQ; University of Chinese Academy of Sciences, 100049, Beijing, China.
Zhang B; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.

Signal Transduct Target Ther ; 5(1): 218, 2020 10 03.

Article in English | MEDLINE | ID: covidwho-1387198

Subject(s)

Antiviral Agents/pharmacology; Betacoronavirus/drug effects; Cardiac Glycosides/pharmacology; Gene Expression Regulation/drug effects; Host-Pathogen Interactions/drug effects; Animals; Antiviral Agents/chemistry; Betacoronavirus/pathogenicity; Biological Products/chemistry; Biological Products/pharmacology; Bufanolides/chemistry; Bufanolides/pharmacology; COVID-19; Cardiac Glycosides/chemistry; Cell Survival/drug effects; Chlorocebus aethiops; Chloroquine/chemistry; Chloroquine/pharmacology; Coronavirus Infections/drug therapy; Coronavirus Infections/virology; Digoxin/chemistry; Digoxin/pharmacology; High-Throughput Screening Assays; Host-Pathogen Interactions/genetics; Humans; Janus Kinases/antagonists & inhibitors; Janus Kinases/genetics; Janus Kinases/metabolism; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/genetics; Mitogen-Activated Protein Kinases/metabolism; NF-E2-Related Factor 2/antagonists & inhibitors; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism; NF-kappa B/antagonists & inhibitors; NF-kappa B/genetics; NF-kappa B/metabolism; Pandemics; Phenanthrenes/chemistry; Phenanthrenes/pharmacology; Pneumonia, Viral/drug therapy; Pneumonia, Viral/virology; SARS-CoV-2; Signal Transduction; Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors; Sodium-Potassium-Exchanging ATPase/genetics; Sodium-Potassium-Exchanging ATPase/metabolism; Vero Cells; Virus Replication/drug effects

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Cardiac Glycosides / Gene Expression Regulation / Host-Pathogen Interactions / Betacoronavirus Type of study: Prognostic study Language: English Journal: Signal Transduct Target Ther Year: 2020 Document Type: Article Affiliation country: S41392-020-00343-Z

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