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Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection.
Guo, Liang; Bi, Wenwen; Wang, Xinling; Xu, Wei; Yan, Renhong; Zhang, Yuanyuan; Zhao, Kai; Li, Yaning; Zhang, Mingfeng; Cai, Xia; Jiang, Shibo; Xie, Youhua; Zhou, Qiang; Lu, Lu; Dang, Bobo.
  • Guo L; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.
  • Bi W; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.
  • Wang X; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
  • Xu W; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.
  • Yan R; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.
  • Zhang Y; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
  • Zhao K; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China.
  • Li Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China.
  • Zhang M; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.
  • Cai X; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.
  • Jiang S; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
  • Xie Y; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.
  • Zhou Q; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.
  • Lu L; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
  • Dang B; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.
Cell Res ; 31(1): 98-100, 2021 01.
Article in English | MEDLINE | ID: covidwho-1387274
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mutation, Missense / Protein Multimerization / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Cell Res Year: 2021 Document Type: Article Affiliation country: S41422-020-00438-W

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mutation, Missense / Protein Multimerization / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Cell Res Year: 2021 Document Type: Article Affiliation country: S41422-020-00438-W