O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule.

Tian, Wenmin; Li, Delin; Zhang, Nan; Bai, Guijie; Yuan, Kai; Xiao, Haixia; Gao, Feng; Chen, Yang; Wong, Catherine C L; Gao, George Fu

Tian, Wenmin; Li, Delin; Zhang, Nan; Bai, Guijie; Yuan, Kai; Xiao, Haixia; Gao, Feng; Chen, Yang; Wong, Catherine C L; Gao, George Fu.

Tian W; Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, Beijing, China.
Li D; School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Zhang N; Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China.
Bai G; Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, Beijing, China.
Yuan K; School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Xiao H; Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China.
Gao F; Shanxi Academy of Advanced Research and Innovation, Taiyuan, Shanxi, China.
Chen Y; Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China.
Wong CCL; Shanxi Academy of Advanced Research and Innovation, Taiyuan, Shanxi, China.
Gao GF; Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China.

Cell Res ; 31(10): 1123-1125, 2021 10.

Article in English | MEDLINE | ID: covidwho-1387286

Subject(s)

SARS-CoV-2/metabolism; Spike Glycoprotein, Coronavirus/metabolism; Amino Acid Sequence; COVID-19/pathology; COVID-19/virology; Chromatography, High Pressure Liquid; Glycopeptides/analysis; Glycopeptides/chemistry; Glycopeptides/metabolism; Glycosylation; HEK293 Cells; Humans; SARS-CoV-2/isolation & purification; Spike Glycoprotein, Coronavirus/chemistry; Spike Glycoprotein, Coronavirus/genetics; Tandem Mass Spectrometry

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 Limits: Humans Language: English Journal: Cell Res Year: 2021 Document Type: Article Affiliation country: S41422-021-00545-2

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