Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
Nat Commun
; 11(1): 5337, 2020 10 21.
Article
in English
| MEDLINE | ID: covidwho-1387319
ABSTRACT
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Binding Sites, Antibody
/
Spike Glycoprotein, Coronavirus
/
Betacoronavirus
/
Antibodies, Monoclonal
/
Antibodies, Viral
Type of study:
Randomized controlled trials
Limits:
Animals
/
Humans
Language:
English
Journal:
Nat Commun
Journal subject:
Biology
/
Science
Year:
2020
Document Type:
Article
Affiliation country:
S41467-020-19146-5
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