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Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection.
Cuperlovic-Culf, Miroslava; Cunningham, Emma L; Teimoorinia, Hossen; Surendra, Anuradha; Pan, Xiaobei; Bennett, Steffany A L; Jung, Mijin; McGuiness, Bernadette; Passmore, Anthony Peter; Beverland, David; Green, Brian D.
  • Cuperlovic-Culf M; Digital Technologies Research Centre, National Research Council of Canada, Ottawa, Canada. miroslava.cuperlovic-culf@nrc-cnrc.gc.ca.
  • Cunningham EL; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. miroslava.cuperlovic-culf@nrc-cnrc.gc.ca.
  • Teimoorinia H; Centre for Public Health, Queen's University Belfast, Block B, Institute of Clinical Sciences, Royal Victoria Hospital Site, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland.
  • Surendra A; NRC Herzberg Astronomy and Astrophysics, 5071 West Saanich Road, Victoria, BC, V9E 2E7, Canada.
  • Pan X; Digital Technologies Research Centre, National Research Council of Canada, Ottawa, Canada.
  • Bennett SAL; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 8 Malone Road, Belfast, BT9 5BN, Northern Ireland.
  • Jung M; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
  • McGuiness B; Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Brain and Mind Research Institute, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
  • Passmore AP; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 8 Malone Road, Belfast, BT9 5BN, Northern Ireland.
  • Beverland D; Centre for Public Health, Queen's University Belfast, Block B, Institute of Clinical Sciences, Royal Victoria Hospital Site, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland.
  • Green BD; Centre for Public Health, Queen's University Belfast, Block B, Institute of Clinical Sciences, Royal Victoria Hospital Site, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland.
Sci Rep ; 11(1): 10629, 2021 05 20.
Article in English | MEDLINE | ID: covidwho-1387475
ABSTRACT
Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the underlying role of metabolism in delirium-susceptibility in the postoperative setting using metabolomic profiling of cerebrospinal fluid and blood taken from the same patients prior to planned orthopaedic surgery. Distance correlation analysis and Random Forest (RF) feature selection were used to determine changes in metabolic networks. We found significant concentration differences in several amino acids, acylcarnitines and polyamines linking delirium-prone patients to known factors in Alzheimer's disease such as monoamine oxidase B (MAOB) protein. Subsequent computational structural comparison between MAOB and angiotensin converting enzyme 2 as well as protein-protein docking analysis showed that there potentially is strong binding of SARS-CoV-2 spike protein to MAOB. The possibility that SARS-CoV-2 influences MAOB activity leading to the observed neurological and platelet-based complications of SARS-CoV-2 infection requires further investigation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Delirium / Spike Glycoprotein, Coronavirus / COVID-19 / Monoamine Oxidase Type of study: Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-90243-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Delirium / Spike Glycoprotein, Coronavirus / COVID-19 / Monoamine Oxidase Type of study: Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-90243-1